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Multiple Sclerosis

Medicine, 2000
Multiple sclerosis is primarily an inflammatory disorder of the brain and spinal cord in which focal lymphocytic infiltration leads to damage of myelin and axons. Initially, inflammation is transient and remyelination occurs but is not durable. Hence, the early course of disease is characterised by episodes of neurological dysfunction that usually ...
Alastair, Compston, Alasdair, Coles
openaire   +5 more sources

Diagnosis and Treatment of Multiple Sclerosis: A Review.

Journal of the American Medical Association (JAMA), 2021
Importance Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system characterized by inflammatory demyelination with axonal transection. MS affects an estimated 900 000 people in the US.
Marisa P. McGinley   +2 more
semanticscholar   +1 more source

The Immune Response in Multiple Sclerosis.

Annual Review of Pathology, 2021
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative disease that affects the central nervous system (CNS). MS is characterized by immune dysregulation, which results in the infiltration of the CNS by immune cells ...
Sofía Rodríguez Murúa   +2 more
semanticscholar   +1 more source

Multiple Sclerosis

Annual Review of Medicine, 2002
▪ Abstract  Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system (CNS). Diagnosis rests upon identifying typical clinical symptoms and interpreting supportive laboratory and radiological investigations. The etiology is unknown; however, strong evidence suggests that MS is an autoimmune disease directed against CNS ...
B Mark, Keegan, John H, Noseworthy
openaire   +2 more sources

Multiple Sclerosis

Nursing Standard, 1990
The Multiple Sclerosis Society of Great Britain and Northern Ireland has an impressive publication programme which includes booklets, sheets, periodicals, and audio and video cassettes. The Society provides general information for adults and children whose lives arc affected directly or indirectly by MS; lecture notes and resource packs for the health ...
Chris Eberhardie, Chris Eberhardie
openaire   +2 more sources

Multiple Sclerosis

Seminars in Neurology, 2016
It is estimated that there are 300,000 people with multiple sclerosis (MS) in the United States and 2.3 million worldwide. Each MS attack can affect function in cognitive, emotional, motoric, sensory, or visual domains. Patients are often struck in the prime of their lives as they attempt to move forward with career, and family. Since the previous 2010
Nicoline, Schiess, Peter A, Calabresi
  +8 more sources

Multiple Sclerosis

Annals of Internal Medicine, 1984
The cause of multiple sclerosis is unknown but seems to be multifactorial. Susceptibility or resistance may be genetically determined; something in the environment interacts with the human host at the proper age to cause biochemical and structural lesions in the central nervous system.
G W, Ellison   +3 more
openaire   +2 more sources

Multiple Sclerosis

Primary Care: Clinics in Office Practice, 2015
Multiple sclerosis (MS) is a chronic, debilitating disease that can have devastating effects. Presentation varies widely in symptoms, pace, and progression. In addition to a thorough history and physical examination, diagnostic tools required to diagnose MS and exclude other diagnoses include MRI, evoked potential testing, and cerebrospinal fluid ...
Daniel Kane, Files   +3 more
openaire   +2 more sources

Identifying Progression In Multiple Sclerosis: New Perspectives.

Annals of Neurology, 2020
The identification of progression in multiple sclerosis is typically retrospective. Given the profound burden of progressive multiple sclerosis, and the recent development of effective treatments for these patients, there is a need to establish measures ...
M. Filippi   +9 more
semanticscholar   +1 more source

Multiple Sclerosis

Annals of Internal Medicine, 2021
Many groundbreaking advances have occurred in the field of multiple sclerosis since this series last reviewed the disorder in 2014. The U.S. Food and Drug Administration has approved 7 new medications for relapsing-remitting multiple sclerosis and approved the first medication for primary progressive multiple sclerosis.
openaire   +2 more sources

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