Results 41 to 50 of about 6,039,132 (349)
Nature Communications, 2019 Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights ...
International Multiple Sclerosis Genetics Consortium
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Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals
Immunity & Ageing, 2023 Background Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification is essential to prevent dependence. Several molecules have been proposed as biomarkers of frailty, but none of them have
Leire Iparraguirre +6 more
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European Journal of Neurology, 2018 Multiple sclerosis (MS) is the commonest non‐traumatic disabling disease to affect young adults. The incidence of MS is increasing worldwide, together with the socioeconomic impact of the disease.
R. Dobson, G. Giovannoni
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Distribution of plaques in the cerebrum in multiple sclerosis
Journal of Neurology Neurosurgery & Psychiatry, 2020 Distribution of plaques in the cerebrum in multiple sclerosis Authors: Brownell B, Hughes JT Year Published: 1962 Number of times cited: 590 Multiple sclerosis (MS) remains an enigmatic disease (or syndrome), reluctant to give up its secrets ...
J. Chataway
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FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
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BMC Neurology, 2021 Background Neuromyelitis optica spectrum disorder (NMOSD) is associated with inflammatory mediators that may also trigger downstream signaling pathways leading to reduce insulin sensitivity.
Zhila Maghbooli +5 more
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Comorbidity in Multiple Sclerosis
Frontiers in Neurology, 2020 Comorbidities in patients with multiple sclerosis (MS) has become an area of increasing interest in the recent years. A comorbidity is defined as any additional disease that coexists in an individual with a given index disease and that is not an obvious ...
M. Magyari, P. Sørensen
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Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
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Frontiers in Molecular Neuroscience, 2018 Multiple Sclerosis is a demyelinating disease of the central nervous system for which no remyelination therapy is available and alternative strategies are being tested.
Iñaki Osorio-Querejeta +8 more
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Inflammation-related plasma and CSF biomarkers for multiple sclerosis
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Molecular biomarkers for multiple sclerosis have so far mainly been limited to measures in cerebrospinal fluid (CSF). Here, we identified additional biomarkers for multiple sclerosis, 2 in plasma as well as 10 in CSF.
Jesse Huang +11 more
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