Results 91 to 100 of about 421,641 (311)

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Preserved auditory-motor synchronization during finger-tapping to music and metronomes at various tempi in progressive multiple sclerosis

Frontiers in Neurology
BackgroundPersons with relapsing and remitting multiple sclerosis (MS) can synchronize steps with music and metronomes at different tempi. However, progressing demyelination, loss of neural connectivity and increased cognitive impairment likely affects ...
Nele Vanbilsen, Nele Vanbilsen, Peter Feys, Peter Feys, Mattia Rosso, Bart Van Wijmeersch, Bart Van Wijmeersch, Daphne Kos, Daphne Kos, Marc Leman, Sonja A. Kotz, Lousin Moumdjian, Lousin Moumdjian, Lousin Moumdjian   +13 more
doaj   +1 more source

Development of a patient reported outcome scale for fatigue in multiple sclerosis: The Neurological Fatigue Index (NFI-MS) [PDF]

, 2010
Roger Mills, Carolyn Young, Julie Pallant, Alan Tennant   +3 more
openalex   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Switching to ublituximab from prior anti-CD20 monoclonal antibody therapy: a case report series

Frontiers in Immunology
IntroductionAnti-CD20 monoclonal antibody (mAb) therapies used to treat multiple sclerosis (MS) differ in their molecular structures, epitope recognition, and mechanisms of CD20-positive (CD20+) cell lysis, which may impact clinical efficacy and ...
Regina Berkovich, Jonathan Calkwood, Heidi Crayton, April Erwin, Simon Faissner, Ralf Gold, Joshua Katz, Mark Leekoff   +7 more
doaj   +1 more source

Diroximel fumarate (DRF) in patients with relapsing–remitting multiple sclerosis: Interim safety and efficacy results from the phase 3 EVOLVE-MS-1 study [PDF]

, 2019
Robert T. Naismith, Jerry S. Wolinsky, Annette Wundes, Christopher LaGanke, Douglas L. Arnold, Dragana Obradović, Mark S. Freedman, Mark Gudesblatt, Tjalf Ziemssen, Boris Kandinov, Ilda Bidollari, Maria Lopez-Bresnahan, Narinder Nangia, David Rezendes, Lili Yang, Hailu Chen, Shifang Liu, Jerome Hanna, Catherine Miller, Richard Leigh-Pemberton   +19 more
openalex   +1 more source

Gregory-MS: list of research papers relevant/not relevant for Multiple Sclerosis research (for machine learning training)

, 2022
António Luís Lopes, B.C. do Amaral
openalex   +1 more source

COVID-19 Symptoms and Immunotherapy in People with Multiple Sclerosis: An Analysis of the COVID-19 in MS Global Data Sharing Initiative Dataset [PDF]

, 2023
Maria A. García‐Dominguez, Bahadar S. Srichawla, Vincent Kipkorir   +2 more
openalex   +1 more source

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics

Advanced Materials, EarlyView.
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian, Bin Feng, Peng Wen, Yufeng Zheng, Xisheng Weng   +13 more
wiley   +1 more source