Results 91 to 100 of about 357,928 (304)

Knowledge Is Power, but Is Ignorance Bliss? Optimising Conversations About Disease Progression in Multiple Sclerosis

Neurology and Therapy, 2019
Communication about multiple sclerosis (MS) disease progression between healthcare professionals (HCPs) and people with MS (PwMS) has historically been considered difficult, and attention to improving it has been neglected.
Patrick Vermersch, Jane Shanahan, Dawn Langdon, David Yeandle, Nektaria Alexandri, Sven Schippling   +5 more
doaj   +1 more source

Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system [PDF]

, 2016
Recent research findings have provided convincing evidence indicating a role for Interleukin-33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases including multiple sclerosis (MS) and Alzheimer’s disease.
Allan, Debbie, Barnett, Susan C., Elliott, Christina, Fairlie-Clarke, Karen J., Jiang, Hui-Rong, Lassmann, Hans, Linnington, Christopher, Schuh, Cornelia   +7 more
core   +2 more sources

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Allelic Variation Investigation of the Estrogen Receptor Within an Australian Multiple Sclerosis Population [PDF]

, 2007
Multiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory demyelinating disease leading to various neurological disabilities. The disorder is more prevalent for women with a ratio of 3:2 female to male.
Attila Szvetko, Bettelli, Butterfield, Confavreux, Czlonkowska, Francesca Fernandez, Fukazawa, Geraldine Detriche, Huan, Isoe-Wada, Jansson, Kikuchi, Kinuta, Liu, Liu Hy, Lotti Tajouri, Lyn R. Griffiths, Mattila, Michael P. Pender, Natalie Colson, Niino, Offner, Peter Csurhes, Polanczyk, Polanczyk, Polman, Savettieri, Sophie Tajouri, Tajouri, Ushiyama, Vukusic, Weinshenker   +31 more
core   +2 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation [PDF]

, 2016
We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations within the major histocompatibility complex (MHC) region, 15 non-MHC loci ...
Andlauer, TF, Antony, G, Arloth, J, Bayas, A, Bechmann, L, Berger, K, Berthele, A, Bertram, L, Bettecken, T, Binder, EB, Buck, D, Carrillo-Roa, T, Chan, A, Cucca, F, Czamara, D, Dankowski, T, Franke, A, Gasperi, C, Gieger, C, Gold, R, Graetz, C, Haas, J, Hecker, M, Hemmer, B, Herms, S, Homuth, G, Infante-Duarte, C, Ising, M, Jöckel, KH, Kacprowski, T, Kloiber, S, Knop, M, Kümpfel, T, Laudes, M, Lichtner, P, Lieb, W, Lill, CM, Limmroth, V, Linker, RA, Loleit, V, Lucae, S, Luessi, F, Meitinger, T, Meuth, SG, Moebus, S, Mulas, A, Mühlau, M, Müller-Myhsok, B, Müller-Nurasyid, M, Nischwitz, S, Nöthen, MM, Paul, F, Petersmann, A, Pitzalis, M, Porcu, E, Pütz, M, Radivojkov-Blagojevic, M, Rawal, R, Ruck, T, Salmen, A, Scheinhardt, MO, Schminke, U, Sidore, C, Stangel, M, Stellmann, JP, Strauch, K, Stürner, KH, Tackenberg, B, Then Bergh, F, Tumani, H, Völzke, H, Waldenberger, M, Warnke, C, Weber, F, Weber, P, Wellmann, J, Wiendl, H, Wildemann, B, Zara, I, Zettl, UK, Ziegler, A, Ziemann, U, Zipp, F, Zoledziewska, M   +83 more
core   +2 more sources

Some factors, enfluencing multiple sclerosis (MS)

Neurology Bulletin, 2002
Some factors, enfluencing multiple sclerosis development, have been studied. Connection of tire disease with living close to metallurgical plants has been confirmed, as well as with prevailing meat products in food and with craniocerebral trauma. For the first time association of multiple sclerosis with infectionous eye diseases has been revealed, as ...
T. V. Matveeva, M. F. Ismagilov, S. A. Ishmanova   +2 more
openaire   +2 more sources

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Mutations in hnRNP A1 drive neurodegeneration and alternative RNA splicing of neuronal gene targets

Neurobiology of Disease
RNA binding protein dysfunction is a pathogenic feature of multiple neurological diseases, including multiple sclerosis (MS). Neurodegeneration (the loss of, or damage to neurons and axons) is the primary driver of disease progression in MS.
Ansalna Ansari, Patricia A. Thibault, Hannah E. Salapa, Joseph-Patrick W.E. Clarke, Michael C. Levin   +4 more
doaj   +1 more source

Validation of the Patient Activation Measure in a Multiple Sclerosis Clinic Sample and Implications for Care

, 2010
Purpose. Patient engagement in multiple sclerosis (MS) care can be challenging at times given the unpredictable disease course, wide range of symptoms, variable therapeutic response to treatment and high rates of patient depression. Patient activation, a
Hibbard, Judith, Hughes, Mary D, Johns, Lisa, Rutter Goodworth, Marie-Christine, Stepleman, Lara, Wright, Dustin   +5 more
core   +1 more source