Results 121 to 130 of about 421,641 (311)

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Migraine headache in Multiple Sclerosis. Is more frequent among MS patients?

, 2023
Alia Saberi, Mandana Ashkan, Hamidreza Hatamian, Ali Ashraf, Enayatollah Homaie Rad, Arash Bakhshi, Kasra Sarlak, Kamal AmirAshjei Asalemi, Nima Broomand Lomer   +8 more
openalex   +1 more source

Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM)

Journal of Magnetic Resonance Imaging, 2016
Yan Zhang, S. Gauthier, Ajay Gupta, J. Comunale, Gloria Chia-Yi Chiang, Dong Zhou, Weiwei Chen, A. Giambrone, Wenzhen Zhu, Yi Wang   +9 more
semanticscholar   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

From routine to selective: how updated MRI guidelines reshape gadolinium use in Germany

Neurological Research and Practice
Magnetic resonance imaging (MRI) is a critical diagnostic tool and monitoring modality for multiple sclerosis (MS), frequently employing gadolinium-based contrast agents (Gd). However, concerns regarding the accumulation of Gd have prompted international
Marc Pawlitzki, Alexander Stahmann, Niklas Frahm, Mathia Kirstein, Melanie Peters, Peter Flachenecker, Tim Friede, Kerstin Hellwig, Dagmar Krefting, Michaela Mai, Clemens Warnke, Uwe K. Zettl, David Ellenberger   +12 more
doaj   +1 more source

Role of Gut Microbiota in Multiple Sclerosis (MS) [PDF]

Hebatalla S. Hashem
openalex   +1 more source

Rigid Hollow Microparticles for Enhanced Focused Ultrasound Treatment Under Optoacoustic Guidance

Advanced Science, EarlyView.
By combining focused ultrasound (FUS) and acoustically active hollow borosilicate microparticles (HBMPs), we demonstrate tunable control over interparticle dynamics and their localized thermal energy deposition. Modulation of acoustic frequency and particle concentration tailors the energy delivery, allowing adaptive, material‐based regulation of ...
Nima Mahkam, Yi Chen, Héctor Estrada, Ananya Amitabh, Amirreza Aghakhani, Metin Sitti, Daniel Razansky   +6 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Managing multiple sclerosis in individuals aged 55 and above: a comprehensive review

Frontiers in Immunology
Multiple Sclerosis (MS) management in individuals aged 55 and above presents unique challenges due to the complex interaction between aging, comorbidities, immunosenescence, and MS pathophysiology.
Óscar Fernández, Óscar Fernández, Per Soelberg Sörensen, Per Soelberg Sörensen, Giancarlo Comi, Giancarlo Comi, Patrick Vermersch, Hans-Peter Hartung, Hans-Peter Hartung, Hans-Peter Hartung, Letizia Leocani, Letizia Leocani, Thomas Berger, Thomas Berger, Bart Van Wijmeersch, Bart Van Wijmeersch, Celia Oreja-Guevara, Celia Oreja-Guevara   +17 more
doaj   +1 more source

Macrocyclic Contrast Materials and dentate nuclei: Our experience in multiple sclerosis (MS) patients

, 2017
Claudia Marsecano
openalex   +1 more source