Results 161 to 170 of about 466,412 (376)

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy

Advanced Science, Volume 12, Issue 15, April 17, 2025.
GABP is found to promote mesangial cell proliferation and ECM deposition through GLI1, while inhibiting GABP or GLI1 prevents the progression of DN by reducing ECM and fibrosis. The research results indicate that a potential therapeutic approach based on inhibiting mesangial cell proliferation and ECM accumulation can effectively treat DN, while GABP ...
Lei Du, Sijie Liu, Yinfei Lu, Dongxue Ren, Xiujuan Yu, Yue Hu, Tingting Yang, Qun Yang, Jingxian Ming, Jiawei Zhang, Xiaoxing Yin, Qian Lu   +11 more
wiley   +1 more source

Longitudinal proxy measurements in multiple sclerosis: patient-proxy agreement on the impact of MS on daily life over a period of two years [PDF]

, 2008
Femke AH van der Linden, Jolijn J Kragt, Margarethe van Bon, Martin Klein, Alan J. Thompson, Henk M. van der Ploeg, Chris H. Polman, Bernard M.J. Uitdehaag   +7 more
openalex   +1 more source

TIA1‐Mediated Stress Granules Promote the Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis through Upregulating IL‐31RA Signaling

Advanced Science, Volume 12, Issue 14, April 10, 2025.
In EAE mice, TIA1 is translocated from the nucleus to the cytoplasm, facilitating SGs formation in neurons. TIA1 knockout in the central nervous system (CNS) of EAE mice yields a notable diminution in neuronal SGs, mitigates CNS inflammatory infiltration, and curtails axonal demyelination.
Xin Hua, Lingting Jin, Zheyu Fang, Yiyun Weng, Yuan Zhang, Jingjing Zhang, Dewei Xie, Yang Tang, Siyu Guo, Yingying Huang, Yilin Dai, Jia Li, Zhihui Huang, Xu Zhang   +13 more
wiley   +1 more source

Managing multiple sclerosis in individuals aged 55 and above: a comprehensive review

Frontiers in Immunology
Multiple Sclerosis (MS) management in individuals aged 55 and above presents unique challenges due to the complex interaction between aging, comorbidities, immunosenescence, and MS pathophysiology.
Óscar Fernández, Óscar Fernández, Per Soelberg Sörensen, Per Soelberg Sörensen, Giancarlo Comi, Giancarlo Comi, Patrick Vermersch, Hans-Peter Hartung, Hans-Peter Hartung, Hans-Peter Hartung, Letizia Leocani, Letizia Leocani, Thomas Berger, Thomas Berger, Bart Van Wijmeersch, Bart Van Wijmeersch, Celia Oreja-Guevara, Celia Oreja-Guevara   +17 more
doaj   +1 more source

Pediatric multiple sclerosis: analysis of clinical and epidemiological aspects according to National MS Society Consensus 2007 [PDF]

, 2008
Maria Lúcia Brito Ferreira, Maria Íris Morais Machado, Maria José Guedes Dantas, Álvaro José Porto Moreira, Adélia Maria de Miranda Henriques‐Souza   +4 more
openalex   +1 more source

Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced Neurodegeneration

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that a high‐salt diet (HSD) induces enhanced reactivity of DAA‐like astrocytes in the hippocampal CA3 region via a tau pathology‐A1R signaling axis, forming a vicious cycle that perpetuates astrocyte reactivity. Neuronal tau pathology releases PAPDs, notably Lcn2, driving neuroinflammation.
Tong‐Yu Rui, He‐Zhou Huang, Kai Zheng, Hong‐Wei Fan, Juan Zhang, Zi‐Yuan Guo, Heng‐Ye Man, Nadezhda Brazhe, Alexey Semyanov, You‐Ming Lu, Dan Liu, Ling‐Qiang Zhu   +11 more
wiley   +1 more source

SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease

Advanced Science, Volume 12, Issue 17, May 8, 2025.
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi, Kai Tao, Xiaomin Wen, Dayun Feng, Zifan Mai, Hui Ding, Honghui Mao, Mingming Wang, Qian Yang, Jie Xiang, Jie Zhang, Shengxi Wu   +11 more
wiley   +1 more source

Expansion of Treg cells using IL-2–mAb complexes to treat multiple sclerosis (MS) [PDF]

, 2009

openalex   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source