Results 171 to 180 of about 466,412 (376)

Middle-range scores from the patient determined disease steps scale reflect varying levels of walking dysfunction in multiple sclerosis

open access: yesBMC Neurology
Background Multiple sclerosis (MS) is a leading cause of neurological disability among young and middle-aged adults worldwide, and disability is measured using a variety of approaches, including patient reported outcome measures (PROMs) such as the ...
Robert Motl   +11 more
doaj   +1 more source

Feasibility of a co-designed online nutrition education program for people with multiple sclerosis [PDF]

open access: yesarXiv
Objective: Diet quality is important for people with multiple sclerosis (MS), but conflicting online information causes them confusion. People with MS want evidence-based MS-specific information to help them make healthy dietary changes, and we co-designed an asynchronous, online nutrition education program (Eating Well with MS) with the MS community ...
arxiv  

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang   +12 more
wiley   +1 more source

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

open access: yesAdvanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni   +15 more
wiley   +1 more source

Mutations in hnRNP A1 drive neurodegeneration and alternative RNA splicing of neuronal gene targets

open access: yesNeurobiology of Disease
RNA binding protein dysfunction is a pathogenic feature of multiple neurological diseases, including multiple sclerosis (MS). Neurodegeneration (the loss of, or damage to neurons and axons) is the primary driver of disease progression in MS.
Ansalna Ansari   +4 more
doaj  

Integrative Multi‐Omics Approaches Reveal Selectivity Profiles and Molecular Mechanisms of FIIN‐2, a Covalent FGFR Inhibitor

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
Using integrative multi‐omics analyses, this study maps FIIN‐2's targets and signaling networks in liver cancer cells, and identifies covalent AMPKα1 binding as a novel autophagy‐activating mechanism. The findings resolve both on‐target FGFR inhibition and off‐target protein engagement, providing a molecular roadmap to refine covalent kinase inhibitors
Ying Fu   +9 more
wiley   +1 more source

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