Results 71 to 80 of about 6,883,088 (299)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Propositionalisation of multiple sequence alignments using probabilistic models [PDF]

, 2008
Multiple sequence alignments play a central role in Bioinformatics. Most alignment representations are designed to facilitate knowledge extraction by human experts.
Mutter, Stefan, Pfahringer, Bernhard, Holmes, Geoffrey   +2 more
core  

Rose: Generating Sequence Families [PDF]

, 1997
Stoye J, Evers D, Meyer F. Rose: Generating Sequence Families. Forschungsberichte.
Stoye, Jens ; https://orcid.org/, Evers, Dirk, Meyer, Folker   +2 more
core   +1 more source

An Optimized System for Multiple Sequence Alignment

2009 International Conference on Reconfigurable Computing and FPGAs, 2009
Multiple sequence alignment (MSA) is one of the essential operations for identifying functional and structural relations among proteins. The execution of an MSA algorithm requires high-performance platforms. This paper presents a hardware system that speeds up the popular MSA software ClustalW.
Çaglar Yilmaz, Mustafa Gök
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

AGenDA: gene prediction by cross-species sequence comparison [PDF]

, 2004
Taher L, Rinner O, Garg S, Sczyrba A, Morgenstern B. AGenDA: gene prediction by cross-species sequence comparison. Nucleic Acids Research. 2004;32(Web Server):W305-W308.Automatic gene prediction is one of the major challenges in computational sequence ...
Sczyrba, Alexander ; https://orcid.org/, Garg, S, Garg, S., Sczyrba, A., Taher, L, Rinner, O, Morgenstern, B, Taher, L., Rinner, O., Morgenstern, Burkhard   +9 more
core   +1 more source

Parallel progressive multiple sequence alignment on reconfigurable meshes

BMC Genomics, 2011
Background One of the most fundamental and challenging tasks in bio-informatics is to identify related sequences and their hidden biological significance.
Nguyen Ken D, Pan Yi, Nong Ge
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Genetic Algorithm For Multiple Sequence Alignment [PDF]

, 2010
[[abstract]]Multiple sequence alignment is an important tool in molecular sequence analysis. This paper presents genetic algorithms to solve multiple sequence alignments.
J.T. Horng;L.C. Wu;J.M. Lin;B.H. Yang
core  

LCSkPOA: enabling banded semi-global partial order alignments via efficient and accurate backbone generation through extended LCSk++

BMC Bioinformatics
Background Most multiple sequence alignment and string-graph alignment algorithms focus on global alignment, but many applications exist for semi-global and local string-graph alignment.
Minindu Weerakoon, Christopher T. Saunders, Haynes Heaton   +2 more
doaj   +1 more source