Results 91 to 100 of about 1,208,960 (264)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

SNiPlay: a web-based tool for detection, management and analysis of SNP (C900) [PDF]

, 2011
The rapidly increasing amount of re-sequencing and genotyping data generated by large-scale genetic diversity projects requires the development of integrated bioinformatics tools able to efficiently manage, analyze, and combine genetic data with the ...
Bacilieri, Roberto, Carrier, Gregory, Dereeper, Alexis, Doligez, Agnès, Le Cunff, Loïc, Nicolas, Stéphane, Péros, Jean-Pierre, Ruiz, Manuel, This, Patrice   +8 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

NSPLformer: exploration of non-stationary progressively learning model for time series prediction

Scientific Reports
Although Transformers perform well in time series prediction, they struggle when dealing with real-world data where the joint distribution changes over time.
Sun Jiaxing, Li Yanhui, Zhao Yuying
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

MIDAS: Computer application for the identification of exact and inaccurate microsatellites in genomic sequences

Revista Cubana de Informática Médica, 2019
Microsatellites are tandem repeat, frequent and diverse short sequences in the genomes of all species, constituting important markers in multiple areas of genomics-based research.
Carlos M. Martínez Ortiz
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

BiLSTM-MLAM: A Multi-Scale Time Series Prediction Model for Sensor Data Based on Bi-LSTM and Local Attention Mechanisms

Sensors
This paper introduces BiLSTM-MLAM, a novel multi-scale time series prediction model. Initially, the approach utilizes bidirectional long short-term memory to capture information from both forward and backward directions in time series data. Subsequently,
Yongxin Fan, Qian Tang, Yangming Guo, Yifei Wei   +3 more
doaj   +1 more source

MDC-Analyzer: A novel degenerate primer design tool for the construction of intelligent mutagenesis libraries with contiguous sites

BioTechniques, 2014
Recent computational and bioinformatics advances have enabled the efficient creation of novel biocatalysts by reducing amino acid variability at hot spot regions.
Lixia Tang, Xiong Wang, Beibei Ru, Hengfei Sun, Jian Huang, Hui Gao   +5 more
doaj   +1 more source

Clinical Sequencing of High-Grade Undifferentiated Sarcomas: A Case Series and Report of an Aggressive Primary Cardiac Tumor With Multiple Oncogenic Drivers [PDF]

JCO Precision Oncology, 2020
Chandan, Kumar-Sinha, Bailey, Anderson, Amer, Heider, Josh N, Vo, Dan R, Robinson, Yi-Mi, Wu, Arul M, Chinnaiyan, Rajen, Mody   +7 more
openaire   +2 more sources