Results 91 to 100 of about 1,205,232 (260)

MIDAS: Computer application for the identification of exact and inaccurate microsatellites in genomic sequences

Revista Cubana de Informática Médica, 2019
Microsatellites are tandem repeat, frequent and diverse short sequences in the genomes of all species, constituting important markers in multiple areas of genomics-based research.
Carlos M. Martínez Ortiz
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

NSPLformer: exploration of non-stationary progressively learning model for time series prediction

Scientific Reports
Although Transformers perform well in time series prediction, they struggle when dealing with real-world data where the joint distribution changes over time.
Sun Jiaxing, Li Yanhui, Zhao Yuying
doaj   +1 more source

BiLSTM-MLAM: A Multi-Scale Time Series Prediction Model for Sensor Data Based on Bi-LSTM and Local Attention Mechanisms

Sensors
This paper introduces BiLSTM-MLAM, a novel multi-scale time series prediction model. Initially, the approach utilizes bidirectional long short-term memory to capture information from both forward and backward directions in time series data. Subsequently,
Yongxin Fan, Qian Tang, Yangming Guo, Yifei Wei   +3 more
doaj   +1 more source

MDC-Analyzer: A novel degenerate primer design tool for the construction of intelligent mutagenesis libraries with contiguous sites

BioTechniques, 2014
Recent computational and bioinformatics advances have enabled the efficient creation of novel biocatalysts by reducing amino acid variability at hot spot regions.
Lixia Tang, Xiong Wang, Beibei Ru, Hengfei Sun, Jian Huang, Hui Gao   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Clinical Sequencing of High-Grade Undifferentiated Sarcomas: A Case Series and Report of an Aggressive Primary Cardiac Tumor With Multiple Oncogenic Drivers [PDF]

JCO Precision Oncology, 2020
Chandan, Kumar-Sinha, Bailey, Anderson, Amer, Heider, Josh N, Vo, Dan R, Robinson, Yi-Mi, Wu, Arul M, Chinnaiyan, Rajen, Mody   +7 more
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

A flying ad-hoc network dataset for early time series classification of grey hole attacks

Scientific Data
Flying ad-hoc networks (FANETs) consist of multiple unmanned aerial vehicles (UAVs) that rely on multi-hop routes for communication. These routes are particularly susceptible to grey hole attacks, necessitating swift and accurate defence to preserve the ...
Charles Hutchins, Leonardo Aniello, Enrico Gerding, Basel Halak   +3 more
doaj   +1 more source