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ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang +11 more
wiley +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source

Dual HIV risk and vulnerabilities among people who inject drugs in Iran: Findings from a nationwide study in 2020

Harm Reduction Journal
Introduction People who inject drugs (PWID) are a key population at risk of HIV in Iran. We measured the prevalence and covariates of HIV-related risk behaviours among PWID in Iran.
Soheil Mehmandoost +7 more
doaj +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu +23 more
wiley +1 more source

Weighted prevalence and 95% confidence intervals of self-reported HIV high-risk behaviour, condomless casual partnerships, transactional partnerships, condomless last sex and both multiple sexual partnership and condomless last sex by sex across 14 PHIA surveys.

Weighted prevalence and 95% confidence intervals of self-reported HIV high-risk behaviour, condomless casual partnerships, transactional partnerships, condomless last sex and both multiple sexual partnership and condomless last sex by sex across 14 PHIA ...
Katrina Sleeman (780057) +52 more
core +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu +5 more
wiley +1 more source

Forest plots showing the predicted prevalence ratios and 95% confidence intervals of self-reporting both multiple sexual partnership and condomless last sex for each of the 14 survey countries by sex.

Forest plots showing the predicted prevalence ratios and 95% confidence intervals of self-reporting both multiple sexual partnership and condomless last sex for each of the 14 survey countries by sex.
Katrina Sleeman (780057) +52 more
core +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang +21 more
wiley +1 more source

Understanding HIV risks among adolescent girls and young women in informal settlements of Nairobi, Kenya: Lessons for DREAMS.

PLoS ONE, 2018
IntroductionHigh incidence of HIV infection among adolescent girls and young women (AGYW) has been attributed to the numerous and often layered vulnerabilities that they encounter including violence against women, unfavourable power relations that are ...
Abdhalah Ziraba +8 more
doaj +1 more source

Forest plots showing the region-specific adjusted prevalence ratios of self-reporting HIV high-risk behaviour, condomless casual partnerships, transactional partnerships, condomless last sex and self-reporting both multiple sexual partnership and condomless last sex for each subgroup.

Forest plots showing the region-specific adjusted prevalence ratios of self-reporting HIV high-risk behaviour, condomless casual partnerships, transactional partnerships, condomless last sex and self-reporting both multiple sexual partnership and ...
Katrina Sleeman (780057) +52 more
core +1 more source

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