Results 41 to 50 of about 986,513 (219)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Multiple solutions for nonresonance impulsive functional differential equations

Electronic Journal of Differential Equations, 2003
In this paper we investigate the existence of multiple solutions for first and second order impulsive functional differential equations with boundary conditions. Our main tool is the Leggett and Williams fixed point theorem.
Mouffak Benchohra, Abdelghani Ouahab
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Superlinear Schrödinger–Kirchhoff type problems involving the fractional p–Laplacian and critical exponent

Advances in Nonlinear Analysis, 2019
This paper concerns the existence and multiplicity of solutions for the Schrődinger–Kirchhoff type problems involving the fractional p–Laplacian and critical exponent.
Xiang Mingqi, Zhang Binlin, Rădulescu Vicenţiu D.   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Steklov problems involving the p(x)-Laplacian

Electronic Journal of Differential Equations, 2014
Under suitable assumptions on the potential of the nonlinearity, we study the existence and multiplicity of solutions for a Steklov problem involving the p(x)-Laplacian. Our approach is based on variational methods.
Ghasem A. Afrouzi, Armin Hadjian, Shapour Heidarkhani   +2 more
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Thermal and stability analysis of silver–water nanofluid flow over unsteady stretching sheet under the influence of heat generation/absorption at the boundary

Nanotechnology Reviews
The aim of this study is to examine a numerical analysis of nanofluid (NF) containing silver (Ag) nanoparticles using water (H2O) as a host fluid through an unsteady stretching sheet with stability analysis.
Shah Nehad Ali, Alabduljabbar Areej Abdullah, Zeeshan, Yook Se-Jin   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Existence of multiple solutions and estimates of extremal values for a Kirchhoff type problem with fast increasing weight and critical nonlinearity

Electronic Journal of Differential Equations, 2018
In this article, we study the Kirchhoff type problem $$ -\Big(a+\epsilon\int_{\mathbb{R}^3} K(x)|\nabla u|^2dx\Big)\hbox{div} (K(x)\nabla u)=\lambda K(x)f(x)|u|^{q-2}u+K(x)|u|^{4}u, $$ where $x\in \mathbb{R}^3$, $10$.
Xiaotao Qian, Jianqing Chen
doaj