Results 171 to 180 of about 508,501 (339)
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
The Astrophysical JournalThe massive semidetached binary with a long-term decreasing orbital period may involve a rapid mass-transfer phase in Case A, and thus, they are good astrophysical laboratories for investigating the evolution of massive binary stars.
Fu-Xing Li +8 more
doaj +1 more source
Star clusters and multiple populations
, 2019 I will review what is known about the star cluster system of the Magellanic Clouds and the stellar populations within them. This will include discussions on various features and their causes from extended main sequence turn-offs and split main sequences in young clusters, to the abundance anomalies seen in intermediate and ancient clusters.
openaire +2 more sources
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Detection of Two Totally Eclipsing B-type Binaries with Extremely Low Mass Ratios
The Astrophysical JournalThe detection of O- and B-type stars with extremely low-mass companions is very important for understanding the formation and evolution of binary stars. However, finding them remains a challenge because the low-mass components in such systems contribute ...
Linfeng Chang +3 more
doaj +1 more source
Southern Very Low Mass Stars and Brown Dwarfs in Wide Binary and Multiple Systems [PDF]
, 2007 J. A. Caballero
openalex +1 more source
Unresolved Multiple Stars and Galactic Clusters’ Mass Estimates [PDF]
, 2021 O. Borodina +3 more
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source