Results 191 to 200 of about 6,137,241 (375)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

First catalogue of new double and multiple stars in the southern hemisphere, discovered at the Lowell Observatory

, 1898
T. J. J. See
openalex   +1 more source

Commission 26: Double and Multiple Stars [PDF]

, 2005
William I. Hartkopf, Christine Allen, John Davis, Francis C. Fekel, P. Lampens, J. F. Ling, E. Oblak, T. D. Oswalt, C. D. Scarfe   +8 more
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Too fast to be single: Tidal evolution and photometric identification of stellar and planetary companions

The Open Journal of Astrophysics
Many stars exist in binary or multiple systems where tidal interactions modify rotational evolution. In single stars, Many stars, including those in binary or multiple systems, exhibit modified rotational evolution due to tidal interactions.
Ilay Kamai, Hagai B. Perets
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Evolutionary States and Triplicity of Four Massive Semidetached Binaries with Long-term Decreasing Orbital Periods in the LMC

The Astrophysical Journal
The massive semidetached binary with a long-term decreasing orbital period may involve a rapid mass-transfer phase in Case A, and thus, they are good astrophysical laboratories for investigating the evolution of massive binary stars.
Fu-Xing Li, Sheng-Bang Qian, Li-ying Zhu, Wen-Ping Liao, Er-gang Zhao, Min-Yu Li, Qi-Bin Sun, Lin-Feng Chang, Wen-Xu Lin   +8 more
doaj   +1 more source

Fourier Analysis ofHubble Space TelescopeFine Guidance Sensor Data of Binary Stars and Application to the Multiple System HD 157948 [PDF]

, 2006
Elliott P. Horch, O. G. Franz, L. H. Wasserman, J. N. Heasley   +3 more
openalex   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Toward Early-type Eclipsing Binaries as Extragalactic Milestones. III. Physical Properties of the O-type Eclipsing Binary OGLE LMC-ECL-21568 in a Quadruple System ,

The Astrophysical Journal
We present the results from a complex study of an eclipsing O-type binary (Aa+Ab) with the orbital period of  P _A = 3.2254367 days that forms part of a higher-order multiple system in a configuration of (A+B)+C. We derived masses of the Aa+Ab binary of 
Mónica Taormina, R.-P. Kudritzki, B. Pilecki, G. Pietrzyński, I. B. Thompson, J. Puls, M. Górski, B. Zgirski, D. Graczyk, W. Gieren, G. Hajdu   +10 more
doaj   +1 more source