Results 61 to 70 of about 791,194 (316)

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

open access: yesFEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang   +9 more
wiley   +1 more source

A Swing of the Pendulum: The Chemodynamics of the Local Stellar Halo Indicate Contributions from Several Radial Merger Events

open access: yesThe Astrophysical Journal, 2023
We find that the chemical abundances and dynamics of APOGEE and GALAH stars in the local stellar halo are inconsistent with a scenario in which the inner halo is primarily composed of debris from a single massive, ancient merger event, as has been ...
Thomas Donlon II, Heidi Jo Newberg
doaj   +1 more source

The Dynamical Significance of Triple Star Systems in Star Clusters [PDF]

open access: yes, 2013
Over the last few decades, observational surveys have revealed that high-order multiple-star systems (e.g. triples, quadruples, etc.), and triples in particular, are common in our Galaxy. In this paper, we consider the dynamical significance of this transformation in our understanding of stellar multiplicity.
arxiv   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

open access: yesFEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten   +10 more
wiley   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

open access: yesFEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung   +6 more
wiley   +1 more source

Speckle Interferometry at SOAR Telescope in 2023

open access: yesThe Astronomical Journal
Results of the speckle-interferometry observations at the 4.1 m Southern Astrophysical Research Telescope obtained during 2023 are presented: 1913 measurements of 1533 resolved pairs or subsystems (median separation 0.″16) and nonresolutions of 552 ...
Andrei Tokovinin   +3 more
doaj   +1 more source

Variable binaries and variables in binaries in the Binary Star Database BDB [PDF]

open access: yes, 2018
The BDB, Binary star DataBase http://bdb.inasan.ru combines data of the catalogues of binary and multiple stars of all observational types. There is a number of ways for variable stars to form or to be a part of binary or multiple systems. We describe how such stars are represented in the database.
arxiv   +1 more source

The main sequences of NGC2808: constraints on the early disc accretion scenario

open access: yes, 2013
[Abridged] A new scenario --early disc accretion-- has been proposed very recently to explain the origin of the multiple population phenomenon in Galactic globular clusters.
Cassisi, Santi, Salaris, Maurizio
core   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

Most Rotational Variables Dominated by a Single Bright Feature Are α 2 CVn Stars

open access: yesThe Astronomical Journal, 2023
We previously reported a rare class of variable star light curves isolated from a sample of 4.7 million candidate variables from the ATLAS survey. Dubbed “UCBH” light curves, they have broad minima and narrow, symmetrical maxima, with typical periods of ...
A. N. Heinze   +2 more
doaj   +1 more source

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