Results 51 to 60 of about 231,758 (259)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Combined Effects of Multiple Stressors: New Insights Into the Influence of Timing and Sequence

Frontiers in Ecology and Evolution, 2019
Complex regimes of stress arise when multiple stressors combine simultaneously, with varying degrees of temporal separation or variation in their sequential order. A manipulative field experiment was run to test whether doses of two stressors (Copper and
Paul R. Brooks, Tasman P. Crowe
doaj   +1 more source

Stressor fluctuations alter mechanisms underpinning seagrass responses to multiple stressors

Marine Pollution Bulletin
Multiple anthropogenic stressors degrade ecosystems globally. A key knowledge gap in multiple stressor research is how variability in stressor intensity (i.e., fluctuations) and synchronicity (i.e., timing of fluctuations) affect biological responses, and the mechanisms underpinning responses.
Ostrowski, Andria, Connolly, Rod M, Rasmussen, Jasmine A, Buelow, Christina A, Sievers, Michael   +4 more
openaire   +3 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Reconceptualizing synergism and antagonism among multiple stressors [PDF]

Ecology and Evolution, 2015
AbstractThe potential for complex synergistic or antagonistic interactions between multiple stressors presents one of the largest uncertainties when predicting ecological change but, despite common use of the terms in the scientific literature, a consensus on their operational definition is still lacking.
Piggott, Jeremy J, Townsend, Colin R, Matthaei, Christoph D   +2 more
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Dietary fatty acids modulate oxidative stress response to air pollution but not to infection

Frontiers in Physiology
Anthropogenic changes to the environment expose wildlife to many pollutants. Among these, tropospheric ozone is of global concern and a highly potent pro-oxidant.
Ann-Kathrin Ziegler, Johan Kjellberg Jensen, Johan Kjellberg Jensen, Lucía Jiménez-Gallardo, Jenny Rissler, Jenny Rissler, Anders Gudmundsson, Jan-Åke Nilsson, Caroline Isaksson   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Marine Microphytobenthic Assemblage Shift along a Natural Shallow-Water CO2 Gradient Subjected to Multiple Environmental Stressors

Journal of Marine Science and Engineering, 2015
Predicting the effects of anthropogenic CO2 emissions on coastal ecosystems requires an understanding of the responses of algae, since these are a vital functional component of shallow-water habitats. We investigated microphytobenthic assemblages on rock
Vivienne R. Johnson, Colin Brownlee, Marco Milazzo, Jason M. Hall-Spencer   +3 more
doaj   +1 more source