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Multiple system atrophy [PDF]

, 2019
Multiple system atrophy (MSA) is a sporadic, adult-onset, relentlessly progressive neurodegenerative disorder, clinically characterized by various combinations of autonomic failure, parkinsonism and ataxia. The neuropathological hallmark of MSA are glial cytoplasmic inclusions consisting of misfolded α-synuclein.
Fanciulli, Alessandra, Stankovic, Iva, Krismer, Florian, Seppi, Klaus, Levin, Johannes, Wenning, Gregor K.   +5 more
core   +8 more sources

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. [PDF]

PLoS ONE, 2013
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh, Gwenaëlle Fillon, Amanda Gysbers, Hanne D Hansen, Manuela Neumann, Christiane Richter-Landsberg, Christian Haass, Bernard Zalc, Catherine Lubetzki, Wei-Ping Gai, Glenda M Halliday, Philipp J Kahle, Poul H Jensen   +12 more
doaj   +3 more sources

Diagnostic challenges in multiple system atrophy

Neuropsychiatric Disease and Treatment, 2018
Diana Obelieniene,1 Sandra Bauzaite,1 Ilona Kulakiene,2 Evaldas Keleras,2 Indre Eitmonaite,3 Daiva Rastenyte1 1Department of Neurology, 2Department of Radiology, 3Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania Abstract ...
Obelieniene D, Bauzaite S, Kulakiene I, Keleras E, Eitmonaite I, Rastenyte D   +5 more
doaj   +1 more source

Multiple system atrophy and cognitive dysfunction

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
As the survival of patients with multiple system atrophy (MSA) is prolonged, patients may present cognitive dysfunction or even dementia in addition to autonomic dysfunction, damage of extrapyramidal system and cerebellar ataxia.
Sen-yang LANG
doaj   +1 more source

Can Autonomic Testing and Imaging Contribute to the Early Diagnosis of Multiple System Atrophy? A Systematic Review and Recommendations by the Movement Disorder Society Multiple System Atrophy Study Group [PDF]

, 2020
Background: In the current consensus diagnostic criteria, the diagnosis of probable multiple system atrophy (MSA) is based solely on clinical findings, whereas neuroimaging findings are listed as aid for the diagnosis of possible MSA.
Stankovic I., Fanciulli A., Calandra Buonaura G., Panicker J. N., Krismer F., Pellecchia M. T., Meissner W. G., Members of the Movement Disorder Society Multiple System Atrophy Study Group, Cortelli P., Seppi K., Palma J. -A., Wenning G. K.   +11 more
core   +2 more sources

Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type [PDF]

Journal of Movement Disorders, 2011
Background and Purpose We investigated the cognitive profiles in a large sample of patients with multiple system atrophy-cerebellar ataxia (MSA-C) and compared directly them in patients with clinical diagnosis of probable MSA-C without dementia and ...
Hyun J. Hong, Sook Keun. Song, Phil Hyu Lee, Young Ho Sohn, Ji E. Lee   +4 more
doaj   +1 more source

Gustatory rhinitis in multiple system atrophy

Acta Oto-Laryngologica Case Reports, 2021
Gustatory rhinitis is a type of nonallergic, noninflammatory rhinitis. A high incidence of rhinorrhea, including gustatory rhinitis, is reported in patients with Parkinson’s disease (PD). Herein, we report a case of gustatory rhinitis in a patient with a
Kaoru Yamakawa, Kenji Kondo, Akihiko Unaki, Hideto Saigusa, Kyohei Horikiri, Tatsuya Yamasoba   +5 more
doaj   +1 more source

Identification of microRNAs for the early diagnosis of Parkinson’s disease and multiple system atrophy [PDF]

Journal of Integrative Neuroscience, 2020
MicroRNAs are reportedly involved in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease and multiple system atrophy. We previously identified 7 differentially expressed microRNAs in Parkinson’s disease patients and control sera
Jia-Hui Yan, Ping Hua, Yong Chen, Lan-Ting Li, Cui-Yu Yu, Lei Yan, Hui Zhang, Ying He, Hao Zheng, Hui Chen, Zhao-Jing Zhang, Qi-Hui Yao, Hui Dong, Wei-Guo Liu
doaj   +1 more source

Freezing of Gait in Multiple System Atrophy

Frontiers in Aging Neuroscience, 2022
Background and PurposeFreezing of gait (FOG) is a common gait disturbance phenomenon in multiple system atrophy (MSA) patients. The current investigation assessed the incidence FOG in a cross-sectional clinical study, and clinical correlations associated
Huaguang Yang, Weiyin Vivian Liu, Shanshan Wang, Wenbin Yang, Changsheng Liu, Zhi Wen, Lanhua Hu, Jinxia Guo, Guoguang Fan, Xiaoguang Luo, Yunfei Zha   +10 more
doaj   +1 more source

Multiple system atrophy - a clinicopathological update

Free Neuropathology, 2020
Multiple system atrophy (MSA) is a fatal, adult-onset neurodegenerative disorder of uncertain etiology, clinically characterized by various combinations of Levo-dopa-unresponsive parkinsonism, and cerebellar, motor, and autonomic dysfunctions.
Kurt A. Jellinger
doaj   +1 more source