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Progressive cerebral atrophy in multiple system atrophy
Journal of the Neurological Sciences, 2002Nine patients with multiple system atrophy (MSA) were studied based on MRI findings of cerebral hemispheric involvement. The age at onset was 56.4+/-8.6 (mean+/-S.D.) years, duration of illness at the first MRI study 2.1+/-1.1 years, duration of illness at the last study 9.7+/-2.6 years, and the follow-up duration 7.6+/-2.3 years.
Masaaki, Konagaya +4 more
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Multiple system atrophy: An update
Movement Disorders, 2003Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that usually manifests in the early sixth decade of life and progresses relentlessly with a mean survival of 9 years. Clinically, MSA is dominated by autonomic/urogenital failure, which may be associated with either levodopa (L-dopa) -unresponsive parkinsonism in 80% of cases (MSA-P
Gregor K, Wenning +3 more
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Survival in multiple system atrophy
Movement Disorders, 2008AbstractWe here report survival in patients with multiple system atrophy (MSA) in a large, prospectively studied group of patients with MSA. Eighty‐five of 100 patients were known to have died. Three patients were rediagnosed as having PD. Twenty‐four patients came to autopsy, which showed MSA in 22 and idiopathic Parkinson's disease in 2.
Anette, Schrag +3 more
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2007
Publisher Summary This chapter deals with the epidemiology, clinical features, pathological characteristics, diagnostic evaluation, and treatment approaches for multiple system atrophy (MSA). MSA is regarded as a distinct disease process with a complex combination of clinical presentations.
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Publisher Summary This chapter deals with the epidemiology, clinical features, pathological characteristics, diagnostic evaluation, and treatment approaches for multiple system atrophy (MSA). MSA is regarded as a distinct disease process with a complex combination of clinical presentations.
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Current Opinion in Neurology, 1998
Although the precise definition of multiple system atrophy has been difficult, a recent consensus in diagnostic criteria for multiple system atrophy has been achieved. This should lead to progress in defining the underlying pathophysiology of the neuroendocrine, autonomic and motor deficits characteristic of multiple system atrophy.
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Although the precise definition of multiple system atrophy has been difficult, a recent consensus in diagnostic criteria for multiple system atrophy has been achieved. This should lead to progress in defining the underlying pathophysiology of the neuroendocrine, autonomic and motor deficits characteristic of multiple system atrophy.
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Pain in multiple system atrophy
Journal of Neurology, 1996Pain is a recognized feature of idiopathic Parkinson's disease (IPD) but has never been studied in multiple system atrophy (MSA), the commonest cause of atypical parkinsonism. We retrospectively analysed histories of pain in 100 consecutive cases of clinically probable MSA.
F, Tison +5 more
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Cerebral atrophy in multiple system atrophy by MRI
Journal of the Neurological Sciences, 2000Cranial magnetic resonance images (MRI) of the cerebral areas of 40 patients with multiple system atrophy (MSA) and of 61 age-matched controls were analyzed. The cerebral area of MSA patients was 131. 95+/-15.89 cm(2) (mean+/-S.D.), which was significantly smaller than that of normal controls at 149.01+/-10.93 cm(2 ...
Y, Horimoto +7 more
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Continuum
This article provides up-to-date diagnosis and management concepts for patients with multiple system atrophy, a rare, sporadic, adult-onset, progressive, and fatal neurodegenerative disorder that is characterized mainly by autonomic and motor dysfunction.Making an accurate and early diagnosis of multiple system atrophy remains challenging because of ...
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This article provides up-to-date diagnosis and management concepts for patients with multiple system atrophy, a rare, sporadic, adult-onset, progressive, and fatal neurodegenerative disorder that is characterized mainly by autonomic and motor dysfunction.Making an accurate and early diagnosis of multiple system atrophy remains challenging because of ...
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Sleep Dysfunction in Multiple System Atrophy
Current Treatment Options in Neurology, 2012Sleep disorders in multiple system atrophy (MSA) are common manifestation and include reduced and fragmented sleep, excessive daytime sleepiness, REM sleep behaviour disorder (RBD), and sleep-disordered breathing. Of these, RBD is the most common (affecting 90 %-100 % of patients with MSA) and is regarded as a red flag for MSA.
FERINI STRAMBI , LUIGI, Marelli S.
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An update on multiple system atrophy
Current Opinion in NeurologyPurpose of review Multiple system atrophy (MSA) is a rapidly progressive synucleinopathy characterized by autonomic failure, parkinsonism, and cerebellar ataxia. Here, we provide an update on α-synuclein's role in MSA pathophysiology and review the new Movement Disorders Society (MDS) diagnostic criteria and the utility of α ...
Iva, Stankovic +2 more
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