Results 171 to 180 of about 218,254 (250)

Systemic delivery of anti-sense oligonucleotide targeting α-synuclein for treatment in a mouse model of multiple system atrophy. [PDF]

Front Aging Neurosci
Spencer B, Quach B, Salehi S, Rissman RA.   +3 more
europepmc   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Association of choroid plexus volume with brain atrophy and glucose metabolism in multiple system atrophy. [PDF]

Sci Rep
Park CJ, Sun Y, Jeong HJ, Na HK, Yoon SH, Lee SK, Lyoo CH, Sohn YH, Jeong SH, Lee PH.   +9 more
europepmc   +1 more source

Quantification of Phosphorylated Tau Protein in Alzheimer's Disease Patients’ Fluids With Electrolyte‐Gated Organic Transistor Biosensors

Advanced Healthcare Materials, EarlyView.
Dementia syndrome affects millions of people in the world, and Alzheimer's disease (AD) is the most common cause. We report the detection of the specific biomarker for AD, p‐tau‐181, from physiological to pathological concentrations in cerebrospinal fluid using an electrolyte‐gated organic transistor biosensor.
Marcello Berto, Pamela A. Manco Urbina, Alessandro Paradisi, Matteo Sensi, Najara Iacovino, Chiara Carbone, Roberta Bedin, Marcello Pinti, Fabio Biscarini, Giovanna Zamboni, Carlo A. Bortolotti   +10 more
wiley   +1 more source

Multiple system atrophy is associated with brain somatic mutations in clonal hematopoiesis genes

Thompson B, Horner D, Morley C, Gustavsson E, Jaunmuktane Z, Proukakis C.   +5 more
europepmc   +1 more source

Autophagy-Lysosome Pathway in Multiple System Atrophy Pathogenesis: The Best Is Yet to Come. [PDF]

Int J Mol Sci
Mavroeidi P, Xilouri M.
europepmc   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Subtypes and predictors of mild cognitive impairment in patients with multiple system atrophy. [PDF]

Chin Med J (Engl)
Guo Y, Sun Y, Yuan R, Dong L, Zhao M, Lv Z, Zhang W, Zhang Y, Huang Y, Chen S, Cui M, Cheng W, Dong Q, Yu J.   +13 more
europepmc   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Transcranial pulse stimulation to treat multiple system atrophy: a case report. [PDF]

J Neurol
Stalter J, Witt K.
europepmc   +1 more source