Results 61 to 70 of about 221,497 (291)

COGNITIVE PERFORMANCE IN MULTIPLE SYSTEM ATROPHY [PDF]

Brain, 1992
The cognitive performance of a group of patients with multiple system atrophy (MSA) of striato-nigral predominance was compared with that of age and IQ matched control subjects, using three tests sensitive to frontal lobe dysfunction and a battery sensitive to memory and learning deficits in Parkinson's disease and dementia of the Alzheimer type.
Robbins, T. W., James, M., Lange, Klaus W., Owen, A. M., Quinn, N. P., Marsden, C. D.   +5 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

International Referral and Elderly Care—A Case of Atypical Parkinsonism and Cerebellar Atrophy

International Journal of Gerontology, 2009
A 66-year-old male patient had a history of hepatitis B, was a hepatitis C carrier, and had hypertension. He was referred to our family medicine international clinic by the Canadian Physician's Referral Service.
Ying-Hua Shieh, Kuong-Hang Fong, Shiou-Dar Su   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy [PDF]

, 2010
Background: Up to the 1950s, there was an ongoing debate about the diversity of hereditary optic neuropathies, in particular as to whether all inherited optic atrophies can be ascribed to Leber's hereditary optic neuropathy (LHON) or represent different ...
Alexander Christiane, Schimpf Simone, Bernd Wissinger, Zrenner, Eberhart, Alavi, M.V., Schimpf, Simone, Auburger Georg, Zrenner, E., Zrenner Eberhart, Schimpf, S., Alavi-Khorassani Moghadam, Marcel Victor, Auburger, Georg, Leo-Kottler, Beate, Marcel V Alavi, Wissinger, Bernd, Christiane Alexander, Nico Fuhrmann, Wissinger, B., Fuhrmann Nico, Beate Leo-Kottler, Alexander, Christiane, Kamenisch, York, Fuhrmann, Nico, Kamenisch, Y., Wissinger Bernd, Auburger, G., Simone Schimpf, Eberhart Zrenner, Georg Auburger, Kamenisch York, York Kamenisch, Alexander, C., Leo-Kottler, B., Leo-Kottler Beate, Alavi Marcel V, Fuhrmann, N.   +35 more
core   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

A challenging case presentation of multiple system atrophy cerebellar type: A rare case report from Somalia

Radiology Case Reports
Multiple system atrophy is a rare and quickly progressing neurological condition characterized by autonomic failure, parkinsonism, or cerebellar ataxia.
Nor Osman Sidow, MD, Abdiwahid Ahmed Ibrahim, MD, Ismail Gedi Ibrahim, MD, Mohamed Sheikh Hassan, MD, Said Abdi Mohamed, MD   +4 more
doaj   +1 more source

in Multiple System Atrophy

, 2020
Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disease with limited symptomatic treatment options. Aggregation of α-synuclein in oligodendrocytes is believed to be a central mechanism of the neurodegenerative process. PD01A and PD03A
Volc, Dieter, Kutzelnigg, Alexandra, Wassilios G. Meissner, Rossella Medori, Péran, Patrice, Monique Galitzky, Vergnet, Sylvain, VERGNET, S., PERAN, P., Patrice Péran, Werner Poewe, Staffler, Günther, Medori, Rossella, GALITZKY, M., MEISSNER, Wassilios, Poewe, Werner, RASCOL, O., Galitzky, Monique, STAFFLER, G., TRAON, A. P., Dieter Volc, SAMIER FOUBERT, Alexandra, MEDORI, R., KUTZELNIGG, A., GALABOVA, G., Alexandra Foubert‐Samier, Sabatini, Umberto, Gergana Galabova, Olivier Rascol, LUHRS, P., Anne Pavy‐Le Traon, SABATINI, U., POEWE, W., SCHNEEBERGER, A., VOLC, D., LAURENS, B., Pavy-Le Traon, Anne, Foubert-Samier, Alexandra, Achim Schneeberger, Brice Laurens, Sylvain Vergnet, Petra Lührs, Günther Staffler, Rascol, Olivier J., Alexandra Kutzelnigg, Lührs, Petra, Umberto Sabatini, Rascol, Olivier, INVESTIGATORS, A. F. F. Study, Galabova, Gergana, Schneeberger, Achim, Laurens, Brice   +51 more
core   +1 more source