Results 31 to 40 of about 221,497 (291)

Multiple system atrophy-cerebellar: A case report and literature review

Radiology Case Reports, 2023
We reported a case of a 48-year-old female patient admitted to the hospital due to balance disorder which progressed rapidly within 1 week. Cerebral magnetic resonance imaging showed significant atrophy and hyperintensities at the middle cerebellar ...
Thi Thuong Doan, MD, Thuy Dung Pham, MD, Duy Duan Nguyen, MD, Dac Hong An Ngo, MD, Trong Binh Le, MD, PhD, Thanh Thao Nguyen, MD, PhD   +5 more
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Asymmetrical putaminal atrophy in parkinsonism-predominant multiple system atrophy (MSA-P): A case report

Radiology Case Reports, 2023
We encountered a case of multiple system atrophy parkinsonian subtype (MSA-P) with right-dominant parkinsonism in the early stage of the disease. Atrophy of the posterolateral putamen and iron deposition are the neuropathological hallmark of MSA-P ...
Koichiro Mori, MD, Akira Yagishita, MD, Toshio Shimizu, MD, PhD   +2 more
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Pan-American Consortium of Multiple System Atrophy (PANMSA). A Pan-American multicentre cohort study of Multiple System Atrophy

Journal of Parkinson’s Disease, 2014
Background: Multiple system atrophy (MSA) is an adult-onset and rapidly progressive, neurodegenerative condition that presents with autonomic dysfunction, parkinsonism, cerebellar ataxia and corticospinal deficits.
Emilia Gatto, Mayela Rodríguez-Violante, Carlos Cosentino, Pedro Chana-Cuevas, Marcelo Miranda, Ellin Gallin, Jose L. Etcheverry, Yesenia Nuñez, Virginia Parisi, Gabriel Persi, Celeste Vecchi, Ana Sanguinetti, Alejandro Alleva, Juliana Aparcana, Luis Torres, Irene Litvan   +15 more
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External anal sphincter electromyography in multiple system atrophy: implications for diagnosis, clinical correlations, and novel insights into prognosis

Neural Regeneration Research, 2023
Multiple system atrophy is a sporadic, progressive, adult-onset, neurodegenerative disorder characterized by autonomic dysfunction symptoms, parkinsonian features, and cerebellar signs in various combinations.
Massimiliano Todisco, Giuseppe Cosentino, Enrico Alfonsi   +2 more
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Diagnosis of multiple system atrophy [PDF]

Autonomic Neuroscience, 2018
Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders, particularly in the early stages of the disease. An autonomic-only presentation can be indistinguishable from pure autonomic failure. Patients presenting with parkinsonism may be misdiagnosed as having Parkinson disease.
Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann   +2 more
openaire   +2 more sources

A genome-wide association study in multiple system atrophy [PDF]

, 2016
OBJECTIVE: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS).
Wüllner, U, Hardy, JA, Albanese, A, Bhatia, Kailash P., Federoff, HJ, Federoff, Monica,, Ross, Owen A.,, CORTELLI, PIETRO, Albanese, A., Widner, H, Traynor, Bryan J, Revesz, Tamas, Ferrucci, L., Bloem, BR, Bhatia, K.P., Bloem, Bastiaan R., Schulte, Claudia, Meissner, W.G., Holton, J.L., Schottlaender, Lucia,, Poewe, W, Tolosa, Eduardo,, Bloem, Bastiaan R, Tolosa, Eduardo, Pellecchia, M.T., Dickson, Dennis W, Rascol, O, Schottlaender, L, Dickson, DW, Price, T Ryan, Mencacci, Niccolo E.,, Mhyre, Timothy R.,, Gasser, T, Dickson, Dennis W., Schottlaender, Lucia, Mhyre, TR, Hardy, John A.,, Revesz, T, the UK Multiple System Atrophy Study Group, Nalls, Michael A., Revesz, T., Lees, Andrew, ], Traynor, Bryan J.,, Ferrucci, Luigi, Houlden, H, Ferreira, Joaquim, Wood, Nicholas W., Traynor, Bryan J., Ling, Helen,, Infante, J., Mhyre, T.R., Oertel, Wolfgang, Wenning, Gregor K.,, Mencacci, NE, Bhatia, Kailash P.,, Mhyre, Timothy R., Rascol, Olivier, Gasser, Thomas, Mok, K, Ferreira, J., Quinn, Niall, Mok, K., Wullner, U., Federoff, M., Wüllner, Ullrich,, Höglinger, GU, Oertel, W, Ross, Owen A., Chelban, Viorica, Revesz, Tamas,, Pellecchia, MT, Wenning, Gregor K., Morris, H.R., O'Sullivan, SS, Mencacci, Niccolo E, Oertel, Wolfgang,, Höglinger, Günter U.,, Bhatia, KP, PELLECCHIA, MARIA TERESA, Ling, H, Widner, Hakan, Gasser, T., Federoff, Howard J.,, Nalls, M.A., Ling, H., Ferreira, Joaquim,, Goldwurm, Stefano, Singleton, Andrew B, Widner, Håkan,, Wood, NW, Ferreira, J, Mok, Kin, Singleton, Andrew B.,, Hardy, John A., Lees, Andrew,, Albanese, Alberto,, Meissner, Wassilios G.,, Gasser, Thomas,, O'Sullivan, Sean S., Morris, Huw R., European Multiple System Atrophy Study Group and the UK Multiple, Wüllner, Ullrich, Goldwurm, S., Sailer, A, Quinn, N, Holton, Janice L, Sailer, Anna,, Holton, JL, Wood, N.W., Bhatia, Kailash P, Ross, O.A., Meissner, Wassilios G., Schulte, C., Ferrucci, Luigi,, Federoff, M, Poewe, W., O'Sullivan, Sean S.,, Price, T. Ryan, Sailer, A., Höglinger, Günter U, Singleton, Andrew B., Widner, H., Chelban, V, Meissner, WG, Höglinger, Günter U., Rascol, Olivier,, Mencacci, N.E., Federoff, Monica, Price, T. Ryan,, Ferrucci, L, Deuschl, G., Scholz, Sonja W., Price, TR, Albanese, Alberto, Hoglinger, G.U., Poewe, Werner,, Scholz, SW, Traynor, BJ, Rascol, O., Lund University., Wood, Nicholas W, Nalls, Michael A.,, Nalls, MA, Pellecchia, Maria Teresa,, Ross, Owen A, Chelban, V., Ling, Helen, Calandra-Buonaura, Giovanna, Federoff, H.J., O'Sullivan, S.S, Scholz, Sonja W, Schottlaender, L., Tolosa, E., Scholz, S.W., Chelban, Viorica,, Wenning, G.K., Quinn, Niall,, Quinn, N., Infante, Jon, Wenning, Gregor K, Houlden, Henry,, Morris, Huw R, Houlden, Henry, Mok, Kin,, Lees, A., Deuschl, Günther,, Mencacci, Niccolo E., Holton, Janice L., Holton, Janice L.,, Tolosa, E, Morris, HR, Lees, A, Hardy, J.A., Infante, Jon,, Federoff, Howard J., Goldwurm, S, Nalls, Michael A, CALANDRA BUONAURA, GIOVANNA, Sailer, Anna, CAPELLARI, SABINA, Oertel, W., Poewe, Werner, Deuschl, G, Scholz, Sonja W.,, Singleton, AB, Meissner, Wassilios G, Schulte, Claudia,, Traynor, B.J., Goldwurm, Stefano,, Infante, J, Singleton, A.B., Hardy, John A, Schulte, C, Ross, OA, Bloem, B.R., Bloem, Bastiaan R.,, European Multiple System Atrophy Study Group [, Deuschl, Günther, Dickson, D.W., Mhyre, Timothy R, Morris, Huw R.,, Dickson, Dennis W.,, Wenning, GK, Houlden, H., Price, T.R., O'Sullivan, Sean S, Wood, Nicholas W.,, Federoff, Howard J   +208 more
core   +1 more source

A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy

Molecular Therapy: Nucleic Acids
Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used viral vectors are not efficient in transforming oligodendrocytes.
Masanori Sawamura, Kiyoshi Tachikawa, Rie Hikawa, Hisako Akiyama, Seiji Kaji, Ken Yasuda, Angel I. Leu, Hyojung Hong, Rajesh Mukthavaram, Pad Chivukula, Hodaka Yamakado, Yoshio Hirabayashi, Ryosuke Takahashi, Shu-ichi Matsuzawa   +13 more
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Differentiation of multiple system atrophy subtypes by gray matter atrophy [PDF]

, 2021
Background and purpose: Multiple system atrophy(MSA) is a rare adult-onset synucleinopathy that can be divided in two subtypes depending on whether the prevalence of its symptoms is more parkinsonian or cerebellar (MSA-P and MSA-C, respectively). The aim
Segura i Fàbregas, Bàrbara, Campabadal Delgado, Anna, Junqué i Plaja, Carme, 1955-, Giraldo, Darly M., Compta, Yaroslau, Abós, Alexandra, Martí Domènech, Ma. Josep, Muñoz, Esteban, Monté Rubio, Gemma C., Pérez Soriano, Alexandra   +9 more
core   +1 more source

Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications

Neuroscience Research
Accumulating evidence suggests that prion-like spread of misfolded α-Synuclein (αSyn) underlies the pathological progression of Lewy body diseases (LBD).
Norihito Uemura
doaj   +1 more source

Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease

npj Parkinson's Disease
The central pathogenesis of Parkinson’s disease involves the misfolding and aggregation of α-synuclein (α-syn). There is a widespread belief that α-syn can propagate in a prion-like manner, and α-syn preformed fibrils (PFFs) have been widely used to ...
Junichiro Ohira, Masanori Sawamura, Kenichi Kawano, Risa Sato, Tomoyuki Taguchi, Tomoyuki Ishimoto, Jun Ueda, Masashi Ikuno, Shu-ichi Matsuzawa, Katsumi Matsuzaki, Ryosuke Takahashi, Hodaka Yamakado   +11 more
doaj   +1 more source