Results 31 to 40 of about 2,232,801 (311)

Exploring the potential benefits of false discovery rates for region-based testing of association with rare genetic variation

Frontiers in Genetics, 2014
When analyzing the data arising from exome or whole-genome sequencing studies, window-based tests, i.e. tests that jointly analyze all genetic data in a small genomic region, are very popular.
ChangJiang eXu, ChangJiang eXu, Antonio eCiampi, Celia M.T. Greenwood, Celia M.T. Greenwood, Celia M.T. Greenwood   +5 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Detection and Evaluation of Spatio-Temporal Spike Patterns in Massively Parallel Spike Train Data with SPADE

Frontiers in Computational Neuroscience, 2017
Repeated, precise sequences of spikes are largely considered a signature of activation of cell assemblies. These repeated sequences are commonly known under the name of spatio-temporal patterns (STPs).
Pietro Quaglio, Alper Yegenoglu, Emiliano Torre, Emiliano Torre, Dominik M. Endres, Sonja Grün, Sonja Grün   +6 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

GET: Global Envelopes in R

Journal of Statistical Software
This work describes the R package GET that implements global envelopes for a general set of d-dimensional vectors T in various applications. A 100(1 - α)% global envelope is a band bounded by two vectors such that the probability that T falls outside ...
Mari Myllymäki, Tomáš Mrkvička
doaj   +1 more source

Statistical evaluation of synchronous spike patterns extracted by Frequent Item Set Mining

Frontiers in Computational Neuroscience, 2013
We recently proposed frequent itemset mining (FIM) as a method to perform an optimized search for patterns of synchronous spikes (item sets) in massively parallel spike trains.
Emiliano eTorre, David ePicado-Muino, Michael eDenker, Christian eBorgelt, Sonja eGrün, Sonja eGrün   +5 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Resampling methods for improved wavelet-based multiple hypothesis testing of parametric maps in functional MRI

, 2007
Two- or three-dimensional wavelet transforms have been considered as a basis for multiple hypothesis testing of parametric maps derived from functional magnetic resonance imaging (fMRI) experiments.
Whitcher, B., Suckling, J., Bullmore, E., Şendur, L.   +3 more
core   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

The effect of the distributed test architecture on the power of testing

, 2008
Copyright @ 2008 Oxford University PressThere has been much interest in testing from finite-state machines (FSMs). If the system under test can be modelled by the (minimal) FSM N then testing from an (minimal) FSM M is testing to check that N is ...
Hierons, RM, Ural, H
core   +1 more source