Results 181 to 190 of about 19,267,755 (288)

The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2015
Yaari G, Benichou JI, Vander Heiden JA, Kleinstein SH, Louzoun Y.   +4 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Multiple time-scales and the developmental dynamics of social systems. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2012
Flack JC.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Combat casualties undergoing lifesaving interventions have decreased heart rate complexity at multiple time scales. [PDF]

J Crit Care, 2013
Cancio LC, Batchinsky AI, Baker WL, Necsoiu C, Salinas J, Goldberger AL, Costa MD.   +6 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Modeling peripheral visual acuity enables discovery of gaze strategies at multiple time scales during natural scene search. [PDF]

J Vis, 2015
Ramkumar P, Fernandes H, Kording K, Segraves M.   +3 more
europepmc   +1 more source

Scaling With Multiple Scaling Factors in Time Series Searching

IEEE Access
Coleman Yu, Tatsuya Akutsu, Raymond Chi-Wing Wong   +2 more
openaire   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Internal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scales. [PDF]

Angew Chem Int Ed Engl, 2013
Lakomek NA, Kaufman JD, Stahl SJ, Louis JM, Grishaev A, Wingfield PT, Bax A.   +6 more
europepmc   +1 more source