Results 171 to 180 of about 7,797,163 (266)

Creatinine–Cystatin C Discrepancy and Renal Transporter Polymorphisms in Japanese Patients with Breast Cancer Receiving Abemaciclib

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Abemaciclib increases serum creatinine by inhibiting renal tubular transporters rather than reducing true glomerular filtration rate, a phenomenon known as pseudo‐acute kidney injury. Creatinine–cystatin C discrepancy and genetic determinants of this elevation remain insufficiently characterized in Japanese patients.
Hiroaki Watanabe   +5 more
wiley   +1 more source

Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil   +6 more
wiley   +1 more source

Green prompt engineering for sustainable generative AI. [PDF]

open access: yesEnviron Sci Ecotechnol
Podder S, Date H, Murthy S.
europepmc   +1 more source

Oogenesis and germinal bed morphology of the brown anole (A. sagrei)

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The brown anole is a model species of the genus Anolis, a squamate (encompassing lizards and snakes) group widely studied in evolutionary, behavioral, and developmental biology. Full genome annotation, the establishment of gene editing techniques, and comprehensive description of reproductive tract morphology and embryogenesis in ...
Bonnie K. Kircher   +12 more
wiley   +1 more source

Oral manifestations in HIV-positive individuals under highly active antiretroviral therapy: a systematic review and meta-analysis of prevalence data. [PDF]

open access: yesBMC Oral Health
Dagnoni TS   +8 more
europepmc   +1 more source

Sensitivity and Criterion Validity of ED100K Lifetime Eating Disorder Diagnoses: A Study Using a National Eating Disorder Quality Register

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Background Epidemiological and genomic studies of eating disorders (ED) require scalable approaches to case ascertainment. The self‐report ED100K questionnaire assesses lifetime ED diagnoses, has been translated into several languages, and has been used in large cohort studies, with data shared or planned for sharing through major repositories
Hunna J. Watson   +6 more
wiley   +1 more source

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