Results 51 to 60 of about 592,190 (345)
The Annals of Mathematical Statistics, 1963 The problem of estimating desired characteristics of a response $X$, where $X = h(y)$ and $y$ is a vector random variable with statistically independent components from known distributions, may be handled by standard Monte Carlo techniques. We are interested in the generalization where several distributions are of interest, one at a time, for each ...
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Dermatology Online Journal, 2003 A 25-year-old man with a 20-year history of asymptomatic nodules on his arms and trunk, which histopathological analysis showed to be consistent with steatocystoma multiplex, is presented. Steatocystoma multiplex is a disorder characterized by multiple, asymptomatic, dermal cysts that usually occur on the trunk and proximal aspects of the extremities ...
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Multiplexity and multireciprocity in directed multiplexes
Physical Review E, 2016 20 pages, 8 ...
Gemmetto, V. +4 more
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Novel Microsatellite Loci for Sebaea aurea (Gentianaceae) and Cross-Amplification in Related Species
Applications in Plant Sciences, 2013 Premise of the study: Microsatellite loci were developed in Sebaea aurea (Gentianaceae) to investigate the functional role of diplostigmaty (i.e., the presence of additional stigmas along the style). Methods and Results: One hundred seventy-four and 180
Jonathan Kissling +3 more
doaj +1 more source
Multiplex gene editing by CRISPR-Cpf1 through autonomous processing of a single crRNA array
Nature Biotechnology, 2016 Targeting of multiple genomic loci with Cas9 is limited by the need for multiple or large expression constructs. Here we show that the ability of Cpf1 to process its own CRISPR RNA (crRNA) can be used to simplify multiplexed genome editing.
Bernd Zetsche +14 more
semanticscholar +1 more source
Molecular Oncology, 2020 Multiplex immunofluorescence is a powerful tool for the simultaneous detection of tissue‐based biomarkers, revolutionising traditional immunohistochemistry.
Amélie Viratham Pulsawatdi +12 more
semanticscholar +1 more source
MultiVERSE: a multiplex and multiplex-heterogeneous network embedding approach [PDF]
Scientific Reports, 2020 Network embedding approaches are gaining momentum to analyse a large variety of networks. Indeed, these approaches have demonstrated their effectiveness in tasks such as community detection, node classification, and link prediction.
L'eo Pio-Lopez +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source