Results 151 to 160 of about 1,907,812 (295)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

IMPROVED MULTIPLEXED IMAGE RECONSTRUCTION PERFORMANCE THROUGH OPTICAL SYSTEM DIVERSITY DESIGN

, 2008
Multiplexed image reconstruction, estimating high resolution images from multiple low resolution images with highly overlapped fields of view, is improved when the magnification of the imagers is diverse.
Sally L. Wood, Hsueh-ban Lan, Marc P. Christensen, Dinesh Rajan   +3 more
core  

Sequential Single-Fluorophore STORM for Highly Multiplexed Nanoscale Protein Mapping

Highly multiplexed super-resolution imaging remains challenging. We present a streamlined sequential multiplexed super-resolution imaging approach using only a single fluorophore, eliminating chromatic aberration and dye incompatibility with standard ...
Shuyuan Zheng, Shengwei Chen, Yang Liu, Hongqiang Ma   +3 more
core   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Comparative Evaluation of Antibody-Oligonucleotide Conjugation Strategies for Multiplexed Imaging Applications. [PDF]

Lab Invest
Caraccio C, van de Klashorst J, Cherkas S, Ancel S, Kempchen TN, Vazquez G, Goltsev Y, Wang YX, Nolan GP, Hickey JW.   +9 more
europepmc   +1 more source

Large‐Area Noise‐Resilient Multiplexing Triboelectric Biomechanical Sensing on Clothing for High‐Precision Full‐Body Motion Capture in Wearables

Advanced Science, EarlyView.
A large‐area, noise‐resilient multiplexed triboelectric sensing garment based on a multilayer shielded architecture and SnS2 nanoflower‐engineered hybrid materials enables interference‐suppressed, high‐fidelity full‐body motion tracking, achieving 0.13% signal misrecognition, 57 dB electromagnetic noise attenuation, and >1.5 N threshold force, while ...
Beibei Shao, Ming‐Han Lu, Wei‐Chen Peng, Wei‐Chun Yang, Yi‐Ting Chen, Jiun‐Wei Fong, Tzu‐Ching Lu, Tai‐Chen Wu, Zhi‐Xian Yan, Kai‐Yuan Hsiao, Jiann‐Yeu Chen, Ming‐Yen Lu, Heng‐Jui Liu, Ruiyuan Liu, Ying‐Chih Lai   +14 more
wiley   +1 more source

Multiplexed Imaging Reveals Immune-Metabolic Niches in Multiple Myeloma Linked to Progression and Bone Disease. [PDF]

Blood Cancer Discov
Roseth IA, Hatscher L, Schiller C, Johnstuen HSS, Slørdahl TS, Hov H, Schapiro D, Standal T.   +7 more
europepmc   +1 more source

Symmetry‐Imposed Selection Rules for Excitations of Nontrivial Plasmonic Topologies

Advanced Science, EarlyView.
A unified group‐theory selection rule governs the excitation of vectorial nearfield topologies across three plasmonic spin states. Derived from first principles, it predicts spin–orbit vortex splitting and multidimensional nested vortices, confirmed by phase‐resolved in situ measurements.
Jie Yang, Pengyi Feng, Fei Han, Weijin Chen, Zhongwei Jin, Jincheng Ni, Yuanjie Yang, Anxue Zhang, Guy A. E. Vandenbosch, Niels Verellen, Ewald Janssens, Jiafu Wang, Benfeng Bai, Cheng‐Wei Qiu, Xuezhi Zheng   +14 more
wiley   +1 more source

Light-Deactivated Fluorescent Probes (FLASH-Off) for Multiplexed Imaging. [PDF]

J Am Chem Soc, 2023
Halabi EA, Weissleder R.
europepmc   +1 more source