Results 41 to 50 of about 13,615 (288)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Monolithic multicore fibre mode-multiplexer

, 2022
We report the first monolithic mode-selective multicore fibre multiplexer for future ultrahigh bandwidth optical communication networks.
Sasaki, Yusuke, Withford, Michael, Love, John, Gross, Simon, Riesen, Nicolas   +4 more
core   +2 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Analysis and Synthesis of Single-Bit Adders for Multi-Bit Adders with Sequential Transfers

Engineering Proceedings
This paper provides an analysis of existing single-digit binary adders from the point of view of their implementation on fans built based on metal-oxide-semiconductor field-effect transistor—MOSFETs.
Sakhybay Tynymbayev, Assel Mukasheva, Kuanyshbek Ibragimov, Adil Mukhamedgali, Gani Sergazin, Teodor Iliev   +5 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

On-Chip Silicon Two-Mode (De)Multiplexer for OFDM/OQAM Data Transmission Based on Grating-Assisted Coupler

IEEE Photonics Journal, 2015
We fabricate and demonstrate on-chip two-mode (de)multiplexing using a tapered asymmetrical grating-assisted contradirectional coupler-based TE0 and TE2 mode multiplexer and demultiplexer on the silicon-on-insulator platform.
Chengcheng Gui, Ya Gao, Zhonglai Zhang, Jian Wang   +3 more
doaj   +1 more source

Multiplexed Supply of a MISO Wireless Power Transfer System for Battery-Free Wireless Sensors

Energies, 2020
Multi-input single output wireless power transmission (MISO-WPT) systems have decisive advantages concerning flexible receiver position in comparison to single coil systems.
Ghada Bouattour, Mohamed Elhawy, Slim Naifar, Christian Viehweger, Houda Ben Jmaa Derbel, Olfa Kanoun   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source