Results 51 to 60 of about 218,978 (281)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On a Sum of More Complex Product-Type Operators from Bloch-Type Spaces to the Weighted-Type Spaces

Axioms, 2023
The aim of the present paper is to completely characterize the boundedness and compactness of a sum operator defined by some more complex products of composition, multiplication, and mth iterated radial derivative operators from Bloch-type spaces to ...
Cheng-Shi Huang, Zhi-Jie Jiang
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On Similarity and Reducing Subspaces of the n-Shift plus Certain Weighted Volterra Operator

Journal of Function Spaces, 2017
Let g(z) be an n-degree polynomial (n≥2). Inspired by Sarason’s result, we introduce the operator T1 defined by the multiplication operator Mg plus the weighted Volterra operator Vg on the Bergman space.
Yucheng Li, Hao Chen, Wenhua Lan
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Boundedness and compactness of a new product-type operator from a general space to Bloch-type spaces

Journal of Inequalities and Applications, 2016
We characterize the boundedness and compactness of a product-type operator, which, among others, includes all the products of the single composition, multiplication, and differentiation operators, from a general space to Bloch-type spaces.
Stevo Stević, Ajay K Sharma, Ram Krishan   +2 more
doaj   +1 more source

A note on Nakano generalized difference sequence space

Advances in Difference Equations, 2020
In this paper, we investigate the necessary conditions on any s-type sequence space to form an operator ideal. As a result, we show that the s-type Nakano generalized difference sequence space X fails to generate an operator ideal.
Awad A. Bakery, Afaf R. Abou Elmatty
doaj   +1 more source

On the compactness and the essential norm of operators defined by infinite tridiagonal matrices

Concrete Operators, 2023
In this article, all sequences u{\boldsymbol{u}}, v{\boldsymbol{v}}, and w{\boldsymbol{w}} that define continuous and compact tridiagonal operators Tu,v,w{T}_{u,v,w} acting on the weighted sequence space lβ2{l}_{\beta }^{2} were characterized ...
Caicedo Alexander, Ramos-Fernández Julio C., Salas-Brown Margot   +2 more
doaj   +1 more source

A non-associative quantum mechanics

, 2005
A non-associative quantum mechanics is proposed in which the product of three and more operators can be non-associative one. The multiplication rules of the octonions define the multiplication rules of the corresponding operators with quantum corrections.
A. I. Nesterov, A. I. Nesterov, B. A. Bernevig, B. Grossman, M. Günaydin, P. Jordan, R. Jackiw, T. Kugo, V. Dzhunushaliev, Vladimir Dzhunushaliev   +9 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source