Results 41 to 50 of about 172,609 (284)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiplication Operators between Lipschitz-Type Spaces on a Tree

International Journal of Mathematics and Mathematical Sciences, 2011
Let ℒ be the space of complex-valued functions 𝑓 on the set of vertices 𝑇 of an infinite tree rooted at 𝑜 such that the difference of the values of 𝑓 at neighboring vertices remains bounded throughout the tree, and let ℒ𝐰 be the set of functions 𝑓∈ℒ such
Robert F. Allen, Flavia Colonna, Glenn R. Easley   +2 more
doaj   +1 more source

Assessment of the Business Proposals Using Frank Aggregation Operators Based on Interval-Valued T-Spherical Fuzzy Information

Journal of Function Spaces, 2022
An interval-valued T-spherical fuzzy set (IVTSFS) is an efficient framework to treat ambiguous and vague information more efficiently. It has four functions consisting of the information in intervals.
Amir Hussain, Kifayat Ullah, Haolun Wang, Mehwish Bari   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Multiplication operators on weighted spaces in the non-locally convex framework

International Journal of Mathematics and Mathematical Sciences, 1997
Let X be a completely regular Hausdorff space, E a topological vector space, V a Nachbin family of weights on X, and CV0(X,E) the weighted space of continuous E-valued functions on X. Let θ:X→C be a mapping, f∈CV0(X,E) and define Mθ(f)=θf (pointwise). In
L. A. Khan, A. B. Thaheem
doaj   +1 more source

Recurrence and mixing recurrence of multiplication operators [PDF]

Mathematica Bohemica
Let $X$ be a Banach space, $\mathcal{B}(X)$ the algebra of bounded linear operators on $X$ and $(J, \|{\cdot}\|_J)$ an admissible Banach ideal of $\mathcal{B}(X)$.
Mohamed Amouch, Hamza Lakrimi
doaj   +1 more source

A Novel Multi-Criteria Group Decision-Making Approach Based on Bonferroni and Heronian Mean Operators under Hesitant 2-Tuple Linguistic Environment

Mathematics, 2021
Ambiguous and uncertain facts can be handled using a hesitant 2-tuple linguistic set (H2TLS), an important expansion of the 2-tuple linguistic set. The vagueness and uncertainty of data can be grabbed by using aggregation operators.
Shahzad Faizi, Wojciech Sałabun, Nisbha Shaheen, Atiq ur Rehman, Jarosław Wątróbski   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Composition Operators and Multiplication Operators on Weighted Spaces of Analytic Functions

International Journal of Mathematics and Mathematical Sciences, 2007
Let V be an arbitrary system of weights on an open connected subset G of ℂN(N≥1) and let B(E) be the Banach algebra of all bounded linear operators on a Banach space E.
J. S. Manhas
doaj   +1 more source