Results 51 to 60 of about 17,450 (322)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Basic quantum subroutines: finding multiple marked elements and summing numbers [PDF]

open access: yesQuantum
We show how to find all $k$ marked elements in a list of size $N$ using the optimal number $O(\sqrt{N k})$ of quantum queries and only a polylogarithmic overhead in the gate complexity, in the setting where one has a small quantum memory.
Joran van Apeldoorn   +2 more
doaj   +1 more source

Models of Computer Calculations

open access: yesКібернетика та комп'ютерні технології, 2022
Introduction. The complexity of computational algorithms for solving typical problems of computational, applied, and discrete mathematics is analyzed from the perspective of the theory of computation, depending on the computer architecture and the used ...
Valerii Zadiraka   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Using Cognitive Diagnostic Models to Evaluate the Two-Process Theory of Matrix Reasoning

open access: yesJournal of Intelligence
Figural matrices are widely used to measure reasoning ability. According to the two-process model of figural matrix reasoning, task performance relies on correspondence finding (linked to induction ability) and goal management (linked to working memory).
Julian Preuß, Franzis Preckel
doaj   +1 more source

Complexity of a Microblogging Social Network in the Framework of Modern Nonlinear Science

open access: yesComplexity, 2018
Recent developments in nonlinear science have caused the formation of a new paradigm called the paradigm of complexity. The self-organized criticality theory constitutes the foundation of this paradigm.
Andrey Dmitriev   +2 more
doaj   +1 more source

A Quadratic Speedup in Finding Nash Equilibria of Quantum Zero-Sum Games [PDF]

open access: yesQuantum
Recent developments in domains such as non-local games, quantum interactive proofs, and quantum generative adversarial networks have renewed interest in quantum game theory and, specifically, quantum zero-sum games.
Francisca Vasconcelos   +4 more
doaj   +1 more source

Improved Twofish Algorithm: A Digital Image Enciphering Application

open access: yesIEEE Access, 2021
With the growth of networks, the Internet of Things (IoT) and new cyber attacks pose threats to privacy and security, secure communication is therefore becoming one of the most crucial concerns.
Tanveer ul Haq   +5 more
doaj   +1 more source

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