Results 31 to 40 of about 41,461 (248)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Multiple Dedekind zeta functions [PDF]

Journal für die reine und angewandte Mathematik (Crelles Journal), 2014
Abstract In this paper we define multiple Dedekind zeta values (MDZV), using a new type of iterated integrals, called iterated integrals on a membrane. One should consider MDZV as a number theoretic generalization of Euler’s multiple zeta values. Over imaginary quadratic fields MDZV capture, in particular, multiple Eisenstein series [6].
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

On the Alienation of Multiplicative and Additive Functions

Annales Mathematicae Silesianae
Given S a semigroup. We study two Pexider-type functional equations fxy+gxy=fx+fy+gxgy,    x, y∈S,f\left( {xy} \right) + g\left( {xy} \right) = f\left( x \right) + f\left( y \right) + g\left( x \right)g\left( y \right), \;\;\;\;x,\;y \in S, and ...
Chakiri Mohamed, Chahbi Abdellatif, Elqorachi Elhoucien   +2 more
doaj   +1 more source

Completely Multiplicative Automatic Functions [PDF]

Integers, 2011
AbstractWe show that a completely multiplicative automatic function which does not have 0 as a value is almost periodic.
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Semimultiplicative generalized arithmetical functions [PDF]

Mathematica Bohemica
By a generalized arithmetical function we mean a function from the set of positive integers to a ring with identity, and we say that a generalized arithmetical function $f$ is semimultiplicative if $f(n) = c_f f_M(n/a_f)$, where $c_f$ is a unit in the ...
Pentti Haukkanen
doaj   +1 more source

Exact solutions of the stochastic new coupled Konno-Oono equation

Results in Physics, 2021
In this paper we consider the stochastic Konno-Oono equation, which is forced by multiplicative noise. In order to find exact solutions of stochastic nonlinear Konno-Oono equations, generalized G′G-expansion method are implemented.
Wael W. Mohammed, Naveed Iqbal, Akbar Ali, Mahmoud El-Morshedy   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

An investigation into multiplicative fractional Weddle’s inequalities

Boundary Value Problems
This article presents a new way to think about multiplicative Weddle inequalities, which is based on multiplicative Riemann-Liouville fractional integrals.
Bouharket Benaissa, Noureddine Azzouz, Hüseyin Budak   +2 more
doaj   +1 more source