Results 61 to 70 of about 302,843 (318)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Simulating multi-fractal sea clutter and surface based on the random multiplicative model

The Journal of Engineering, 2019
It has been proved that the multi-fractal sea clutter can be simulated by the three-partitioned random multiplicative model. This study constructs multi-fractal sequences with similar multiplicative factors of the sea clutter of the IPIX radar and ...
Caiping Xi, Gang Xiong, Yonghong Yang, Si Chen   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effects of the Wiener Process on the Solutions of the Stochastic Fractional Zakharov System

Mathematics, 2022
We consider in this article the stochastic fractional Zakharov system derived by the multiplicative Wiener process in the Stratonovich sense. We utilize two distinct methods, the Riccati–Bernoulli sub-ODE method and Jacobi elliptic function method, to ...
Farah M. Al-Askar, Wael W. Mohammed, Mohammad Alshammari, M. El-Morshedy   +3 more
doaj   +1 more source

Multiplicative functionals and entire functions, II [PDF]

Studia Mathematica, 1997
[Part I, cf. Stud. Math. 119, No. 3, 289-297 (1996; Zbl 0868.46037).] The following result is proved in this very interesting paper: Let \(A\) be a complex Banach algebra with a unit \(e\), let \(F\) be a nonconstant entire function, and let \(T\) be a linear functional with \(T(e) = 1\) and such that \(T\circ F\) defined from \(A\) to the complex ...
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Recursive formulae for the multiplicative partition function

International Journal of Mathematics and Mathematical Sciences, 1999
For a positive integer n, let f(n) be the number of essentially different ways of writing n as a product of factors greater than 1, where two factorizations of a positive integer are said to be essentially the same if they differ only in the order of the
Jun Kyo Kim, Sang Guen Hahn
doaj   +1 more source

Multiple Sclerosis Functional Composite [PDF]

Archives of Neuropsychiatry, 2018
Functional disorders due to multiple sclerosis are evaluated using rating scales. EDSS is a scant which is very inadequate in evaluating cognitive functions, is significantly limited in evaluating upper extremity functions and is highly difficult to repeat. Multiple Sclerosis Functional Composite (MSFC) is considered as a test that has been proposed in
openaire   +2 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

The multiplicity function of galaxies [PDF]

Astronomy & Astrophysics, 2003
10 pages, 10 figures.
LONGO, GIUSEPPE, E. PUDDU, E. DE FILIPPIS, S. ANDREON, R. R. GAL   +4 more
openaire   +5 more sources