Results 41 to 50 of about 4,918 (271)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Certain Spaces of Functions over the Field of Non-Newtonian Complex Numbers
Abstract and Applied Analysis, 2014 This paper is devoted to investigate some characteristic features of complex numbers and functions in terms of non-Newtonian calculus. Following Grossman and Katz, (Non-Newtonian Calculus, Lee Press, Piegon Cove, Massachusetts, 1972), we construct the ...
Ahmet Faruk Çakmak, Feyzi Başar
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Fixed Point Results on Multiplicative Semi-Metric Space
Journal of Scientific Research, 2020 In this paper we introduce the notion of the Multiplicative Semi-Metric Space and proved common fixed point theorems. We establish fixed point theorems for four self-maps which can be extended to derive common fixed point theorems involving any finite number of mappings in Multiplicative Semi Metric Space. Further examples are discussed to show
V. Srinivas, B. Vijayabaskerreddy
openaire +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Online Metric Allocation and Time-Varying Regularization [PDF]
, 2022 We introduce a general online allocation problem that connects several of the most fundamental problems in online optimization. Let M be an n-point metric space. Consider a resource that can be allocated in arbitrary fractions to the points of M. At each
Coester, Christian, Bansal, Nikhil
core +1 more source
Multipled fixed point theorems in cone metric spaces [PDF]
Fixed Point Theory and Applications, 2014 The authors use the method, first applied by \textit{V. Berinde} [Nonlinear Anal., Theory Methods Appl., Ser. A, Theory Methods 74, No. 18, 7347--7355 (2011; Zbl 1235.54024)], to obtain results about \(m\)-order fixed points and coincidence and common \(m\)-order fixed points of cyclic type for mappings depending on \(m\) variables in cone metric ...
Olaoluwa, Hallowed, Olaleru, Jonhson
openaire +1 more source