Results 281 to 290 of about 504,368 (352)

Overall survival with immune checkpoint inhibitors across treatment settings and clinical and PD-L1-defined subgroups in advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis of randomized trials. [PDF]

Front Immunol
Wang B, Han X, Shen Z.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Five Conserved microRNAs Dominate the Small-RNA Pool of Three Arid-Zone Camel-Forage Plants: De Novo Repertoires and a Species-Matched Test of Cross-Kingdom Targeting in the Dromedary. [PDF]

Genes (Basel)
Zoziuk M, Ali A, Djibagao AD, Montesano C, Potestà M, Minchella A, Terrinoni A, Caroleo MC, Cappelli G, Koroliouk D, Jimale MA, Ciani E, Colizzi V.   +12 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Programming Intrinsic States of Solvent-Free Glycolipids through Molecular Architecture and Thermal History. [PDF]

ACS Omega
Kim W, Hogan DE, Maier RM, Kim M.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Comment on "Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)". [PDF]

Int Forum Allergy Rhinol
Malik MMUD.
europepmc   +1 more source

Diacarnusins A-F, nor-Terpene Endoperoxides of the Red Sea Sponge Diacarnus erythraeanus. [PDF]

J Nat Prod
Hasib Afana R, Raijman-Nagar L, Ilan M, Carmeli S.   +3 more
europepmc   +1 more source

Serum Redox Biomarkers in Canine Mast Cell Tumors: Exploratory Associations with Proliferative Activity and Clinicopathological Features. [PDF]

Antioxidants (Basel)
Ginoudis A, Pardali D, Mylonakis ME, Chaintoutis S, Galiatsatos D, Thomas AL, Polizopoulou Z.   +6 more
europepmc   +1 more source

To adjust or not to adjust? Matching statistical choices to scientific questions in exercise physiology and sport science. [PDF]

Front Physiol
Schappacher-Tilp G, Tilp M.
europepmc   +1 more source