Results 71 to 80 of about 226,228 (269)
LINGUISTIC PERSONALITY: MULTIPLICITY AND FAKE
Філологічні студії, 2017 The article characterizes lingual personality in terms of aspects of multiplicity and fake. The understanding of lingual personality has recently acquired new interpretations.
Olena Gryshchenko
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Multiple targets for multiple sclerosis
Genes & Diseases, 2015 Multiple sclerosis (MS), a leading cause of non-traumatic disability in young adults, is a chronic inflammatory demyelinating disease of the central nervous system (CNS) associated with aberrant autoimmune responses. It has long been thought that therapeutic development should be centered on immunomodulatory agents.
Hu, Li-Tian, Sun, Fei, Chen, Guo-Jun
openaire +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Singular boundary-value problems with variable coefficients on the positive half-line
Electronic Journal of Differential Equations, 2013 This work concerns the existence and the multiplicity of solutions for singular boundary-value problems with a variable coefficient, posed on the positive half-line.
Smail Djebali, Ouiza Saifi, Samira Zahar
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Transactions of the Association of European Schools of Planning, 2017 A trend in the planning discourse tends to portray the local in a positive light. This paper critically examines localism and regionalism, from a theoretical point of view, to find out whether this positive outlook may be maintained.
Ali Madanipoura
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Memory and music in Mikhail Bulgakov's The Master and Margarita: Defying the regime [PDF]
Logos et Littera: Interdisciplinary Approaches to Text, 2017 Mikhail Bulgakov’s The Master and Margarita reveals intricate intersections, which are negotiated via memory and writing. Witnessing the collapse of the Russian Empire and the emergence of the Soviet Union, Bulgakov devises multiple ways to engage not ...
Nataliya Shpylova-Saeed +1 more
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