Results 41 to 50 of about 157,130 (289)

The Fate of the Landau Levels under Perturbations of Constant Sign

open access: yes, 2009
We show that the Landau levels cease to be eigenvalues if we perturb the 2D Schr\"odinger operator with constant magnetic field, by bounded electric potentials of fixed sign.
Klopp, Frédéric, Raikov, Georgi
core   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Morse index and multiplicity of min-max minimal hypersurfaces

open access: yes, 2016
The Min-max Theory for the area functional, started by Almgren in the early 1960s and greatly improved by Pitts in 1981, was left incomplete because it gave no Morse index estimate for the min-max minimal hypersurface. We advance the theory further and
Marques, Fernando C., Neves, André
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Problems solving in the integral calculus and the determination of the area under the curve

open access: yesREMATEC. Revista de Matemática, Ensino e Cultura
In Integral Calculus the classic problem is the determination of the area under the curve, when said region is not expressible in terms of elementary figures.
Juan E. N´apoles Vald´es   +1 more
doaj   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

On Theoretical Incomprehensibility

open access: yesPhilosophies, 2019
This contribution tentatively outlines the presumed conceptual duality between the issues of incompleteness and incomprehensibility—The first being more formal in nature and able to be declined in various ways until specified in the literature as ...
Gianfranco Minati
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Carlo Rovelli, L’ordine del tempo

open access: yesTechne, 2020
Carlo Rovelli’s book is a journey through time and space that brings us to the essence of the human being and, I would like to say, of the technological man who lives in us.
Alessandra Zanelli
doaj   +1 more source

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

open access: yesFEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source

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