Results 41 to 50 of about 7,135 (308)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Parity and generalized multiplicity [PDF]
, 1991 Assuming that X and Y are Banach spaces and that T is a path of linear Fredholm operators with invertible endpoints, in [F-Pl] we defined a homotopy invariant "the parity of T .
Fitzpatrickp. +2 more
core
ontextualization in Science teaching: the voices of those involved in creating theoretical and methodological texts for the ENEM (Exame Nacional do Ensino Médio [National High-school Exam]) [PDF]
Investigações em Ensino de Ciências, 2012 This paper aims to analyse understanding of the concept of contextualization in Science teaching implicit in questions for the ENEM, from the perspective of those involved in creating theoretical and methodological texts for this exam, and with the ...
Carolina dos Santos Fernandes +1 more
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Problems solving in the integral calculus and the determination of the area under the curve
REMATEC. Revista de Matemática, Ensino e CulturaIn Integral Calculus the classic problem is the determination of the area under the curve, when said region is not expressible in terms of elementary figures.
Juan E. N´apoles Vald´es +1 more
doaj +1 more source
Time and Life in the Relational Universe: Prolegomena to an Integral Paradigm of Natural Philosophy
Philosophies, 2018 Relational ideas for our description of the natural world can be traced to the concept of Anaxagoras on the multiplicity of basic particles, later called “homoiomeroi” by Aristotle, that constitute the Universe and have the same nature as the
Abir U. Igamberdiev
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
A hooray for Poisson approximation [PDF]
Discrete Mathematics & Theoretical Computer Science, 2005 We give several examples for Poisson approximation of quantities of interest in the analysis of algorithms: the distribution of node depth in a binary search tree, the distribution of the number of losers in an election algorithm and the discounted ...
Rudolf Grübel
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source