Results 271 to 280 of about 36,909 (312)

MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe

open access: yesCancer Science, Volume 117, Issue 2, Page 377-392, February 2026.
MASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Ke Wang   +4 more
wiley   +1 more source

LncRNA H19‐Encoded Micropeptide altH19 Promotes DNA Replication and Mitosis in Myeloma Cells by Enhancing the Phosphorylation of CDK2 at Threonine 160

open access: yesCell Proliferation, Volume 59, Issue 2, February 2026.
The micropeptide altH19 interacts with phosphorylated CDK2 (p‐CDK2), subsequently activating CDK2 phosphorylation. This enhances the downstream E2F1 target gene RB activity, which accelerates DNA replication, ultimately leading to rapid myeloma cell mitosis and proliferation.
Yaxin Zhang   +6 more
wiley   +1 more source

Centrosome amplification primes ovarian cancer cells for apoptosis and potentiates the response to chemotherapy. [PDF]

open access: yesPLoS Biol
Edwards F   +16 more
europepmc   +1 more source

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