Results 31 to 40 of about 71,871 (269)

Robust and accurate performance anomaly detection and prediction for cloud applications: a novel ensemble learning-based framework

Journal of Cloud Computing: Advances, Systems and Applications, 2023
Effectively detecting run-time performance anomalies is crucial for clouds to identify abnormal performance behavior and forestall future incidents. To be used for real-world applications, an effective anomaly detection framework should meet three main ...
Ruyue Xin, Hongyun Liu, Peng Chen, Zhiming Zhao   +3 more
doaj   +1 more source

A Review of Two Multiscale Methods for the Simulation of Macromolecular Assemblies: Multiscale Perturbation and Multiscale Factorization [PDF]

Computation, 2015
Many mesoscopic N-atom systems derive their structural and dynamical properties from processes coupled across multiple scales in space and time. That is, they simultaneously deform or display collective behaviors, while experiencing atomic scale vibrations and collisions. Due to the large number of atoms involved and the need to simulate over long time
Pankavich, Stephen, Ortoleva, Peter
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Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Nature Communications, 2021
Synapses are surrounded by an extracellular matrix (ECM) of extremely long-lived proteins that is thought to only be remodeled by proteolysis and de novo synthesis.
Tal M. Dankovich, Rahul Kaushik, Linda H. M. Olsthoorn, Gabriel Cassinelli Petersen, Philipp Emanuel Giro, Verena Kluever, Paola Agüi-Gonzalez, Katharina Grewe, Guobin Bao, Sabine Beuermann, Hannah Abdul Hadi, Jose Doeren, Simon Klöppner, Benjamin H. Cooper, Alexander Dityatev, Silvio O. Rizzoli   +15 more
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Community effort endorsing multiscale modelling, multiscale data science and multiscale computing for systems medicine [PDF]

Briefings in Bioinformatics, 2017
Systems medicine holds many promises, but has so far provided only a limited number of proofs of principle. To address this road block, possible barriers and challenges of translating systems medicine into clinical practice need to be identified and addressed.
Massimiliano Zanin, Ivan Chorbev, Blaz Stres, Egils Stalidzans, Julio Vera, Paolo Tieri, Filippo Castiglione, Derek Groen, Huiru Zheng, Jan Baumbach, Johannes A. Schmid, José Basilio, Peter Klimek, Natasa Debeljak, Damjana Rozman, Harald H. H. W. Schmidt   +15 more
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Multiscale Cancer Modeling [PDF]

Annual Review of Biomedical Engineering, 2011
Simulating cancer behavior across multiple biological scales in space and time, i.e., multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine hypotheses, focus experiments, and enable more accurate predictions. A growing number of examples illustrate the value of this approach in providing quantitative insights in the
Deisboeck, Thomas S., Wang, Zhihui, Macklin, Paul, Cristini, Vittorio   +3 more
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Acceleration and suppression of resistance development by antibiotic combinations

BMC Genomics, 2017
Background The emergence and spread of antibiotic resistance in bacteria is becoming a global public health problem. Combination therapy, i.e., the simultaneous use of multiple antibiotics, is used for long-term treatment to suppress the emergence of ...
Shingo Suzuki, Takaaki Horinouchi, Chikara Furusawa   +2 more
doaj   +1 more source

Multiscale brain modelling [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2005
A central difficulty of brain modelling is to span the range of spatio-temporal scales from synapses to the whole brain. This paper overviews results from a recent model of the generation of brain electrical activity that incorporates both basic microscopic neurophysiology and large-scale brain anatomy to predict brain electrical activity at scales ...
P A, Robinson, C J, Rennie, D L, Rowe, S C, O'Connor, E, Gordon   +4 more
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Do seconds make a difference? Investigating strain-specific behavior of yeast in dynamic glucose environments

Microbial Cell Factories
Background When applied for industrial-scale bioproduction, cells are subjected to ever-changing cultivation environments due to bioreactor heterogeneities, which can significantly influence their growth and production behavior. Cultivating and comparing
Luisa Blöbaum, Markus Bünker, Julian Schmitz   +2 more
doaj   +1 more source

Multiscale Computing with the Multiscale Modeling Library and Runtime Environment

Procedia Computer Science, 2013
AbstractWe introduce a software tool to simulate multiscale models: the Multiscale Coupling Library and Environment 2 (MUSCLE 2). MUSCLE 2 is a component-based modeling tool inspired by the multiscale modeling and simulation framework, with an easy-to-use API which supports Java, C++, C, and Fortran.
Joris Borgdorff, Mariusz Mamonski, Bartosz Bosak, Derek Groen, Mohamed Ben Belgacem, Krzysztof Kurowski, Alfons G. Hoekstra   +6 more
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The heterogeneous multiscale method [PDF]

Acta Numerica, 2012
The heterogeneous multiscale method (HMM), a general framework for designing multiscale algorithms, is reviewed. Emphasis is given to the error analysis that comes naturally with the framework. Examples of finite element and finite difference HMM are presented.
Assyr Abdulle, Weinan E, Björn Engquist, Eric Vanden-Eijnden   +3 more
openaire   +1 more source