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Multitarget Cardiovascular Drugs
Current Medicinal Chemistry, 2011Cardiovascular disease is the number one cause of death globally. Design of cardiovascular drugs based on new paradigms is therefore a prominent goal of medicinal chemistry. Designed multiple ligands, targeting two or more proteins involved in pathogenesis of disease have become a viable concept in drug discovery.
U, Trstenjak, D, Kikelj
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Multitarget Antithrombotic Drugs
Current Topics in Medicinal Chemistry, 2011Thromboembolic disorders are still the leading causes of morbidity and mortality in developed societies. Therefore, prophylaxis and treatment of arterial and venous thrombosis are among the main therapeutic challenges nowadays. Simultaneous action on several targets involved in pathology of thrombosis offers potential advantages compared to existing ...
Miloš, Ilić +2 more
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Computational Multitarget Drug Design
Journal of Chemical Information and Modeling, 2017Designing drugs that can simultaneously interact with multiple targets is a promising approach for treating complicated diseases. Compared to using combinations of single target drugs, multitarget drugs have advantages of higher efficacy, improved safety profile, and simpler administration.
Weilin Zhang, Jianfeng Pei, Luhua Lai
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Forging Ahead the Repositioning of Multitargeted Drug Ivermectin
Current Drug Delivery, 2023Abstract:With the advent of ivermectin, tremendous improvement in public health has been observed, especially in the treatment of onchocerciasis and lymphatic filariasis that created chaos mostly in rural, sub-Saharan Africa and Latin American countries.
Srividya Atmakuri +5 more
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Polypharmacology in a Single Drug: Multitarget Drugs
Current Medicinal Chemistry, 2013Polypharmacology offers a model for the way drug discovery must evolve to develop therapies most suited to treating currently incurable diseases. It is driven by a worldwide demand for safer, more effective, and affordable medicines against the most complex diseases, and by the failures of modern drug discovery to provide these.
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ChemMedChem, 2015
AbstractMultitargeting is a valuable concept in drug design for the development of effective drugs for the treatment of multifactorial diseases. This concept has most frequently been realized by incorporating two or more pharmacophores into a single hybrid molecule.
Péter, Mátyus, Christina L L, Chai
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AbstractMultitargeting is a valuable concept in drug design for the development of effective drugs for the treatment of multifactorial diseases. This concept has most frequently been realized by incorporating two or more pharmacophores into a single hybrid molecule.
Péter, Mátyus, Christina L L, Chai
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Computational Approaches in Multitarget Drug Discovery
2018Current therapeutic strategies entail identifying and characterizing a single protein receptor whose inhibition is likely to result in the successful treatment of a disease of interest, and testing experimentally large libraries of small molecule compounds "in vitro" and "in vivo" to identify promising inhibitors in model systems and determine if the ...
Luciana, Scotti +4 more
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Nanotechnology, a booster for the multitarget drug verteporfin
Journal of Drug Delivery Science and Technology, 2021Abstract In these recent years nanotechnology has gained interest as a powerful tool for drug delivery. It allows to overcome important drawbacks such as drug poor physico-chemical proprieties, toxicity and bioavailability challenges thereby ensuring better therapeutic efficacy with low side-effects and, sometimes, it permits to discover new drug ...
Greco, A +8 more
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Multitarget Drug Design for Neurodegenerative Diseases
2018Multitarget drug design for neurodegenerative ...
Catto Marco +4 more
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Selenoureido-iminosugars: A new family of multitarget drugs
European Journal of Medicinal Chemistry, 2016Herein we report the synthesis of N-alkylated deoxynojirimycin derivatives decorated with a selenoureido motif at the hydrocarbon tether as an example of unprecedented multitarget agents. Title compounds were designed as dual drugs for tackling simultaneously the Gaucher disease (by selective inhibition of β-glucosidase, Ki = 1.6-5.5 μM, with improved ...
Olsen, Jacob Ingemar +5 more
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