Results 171 to 180 of about 9,651 (201)

Structure–Activity Relationship Studies for Multitarget Antithrombotic Drugs

Future Medicinal Chemistry, 2016
Thrombosis is a complex process involving multiple pathways. Currently, therapy relies on the combination of two or more antithrombotic drugs, showing that inhibiting more than one target provides benefits in the prevention and treatment of thrombosis.
Ana R, Neves, Marta, Correia-da-Silva, Emília, Sousa, Madalena, Pinto   +3 more
openaire   +2 more sources

Multitarget Drugs of Plants Origin Acting on Alzheimer's Disease

Current Medicinal Chemistry, 2013
The etiopathology of Alzheimer's disease (AD) is extremely complex and heterogeneous, often associated with comorbidities. As a result it may be unlikely that AD may be mitigated by drug acting on a single specific target. The current tendency in drug design and discovery in AD is the rational design or "serendipitous" discovery of new drug entities ...
P, Russo, A, Frustaci, A, Del Bufalo, M, Fini, A, Cesario   +4 more
openaire   +2 more sources

Biodegradable Multitargeting Nanoconjugates for Drug Delivery

2008
Combination of several treatment regimens such as chemotherapy, radiotherapy, and surgery was always more beneficial for cancer patients than monotherapy. Advances in combination chemotherapy in the 1970s brought improvement of life quality and prolonged patient survival.
Julia Y. Ljubimova, Keith L. Black, Alexander V. Ljubimov, Eggehard Holler   +3 more
openaire   +1 more source

ChemInform Abstract: Multitarget Drugs: An Epigenetic Epiphany

ChemInform, 2016
AbstractReview: [71 refs.
openaire   +1 more source

Molecular hybridization: a powerful tool for multitarget drug discovery

Expert Opinion on Drug Discovery
The current drug discovery paradigm of 'one drug, multiple targets' has gained attention from both the academic medicinal chemistry community and the pharmaceutical industry. This is in response to the urgent need for effective agents to treat multifactorial chronic diseases.
Pedro, de Sena Murteira Pinheiro, Lucas Silva, Franco, Tadeu Lima, Montagnoli, Carlos Alberto Manssour, Fraga   +3 more
openaire   +2 more sources

Analogues of cannabinoids as multitarget drugs in the treatment of Alzheimer's disease

European Journal of Pharmacology, 2021
Angel Agis-Torres, Monica Sollhuber, Moises Garcia-Arencibia   +2 more
exaly  

Identification of Potential Multitarget Antimalarial Drugs

JAMA, 2005
Ekachai, Jenwitheesuk, Ram, Samudrala
openaire   +2 more sources

Multitargeted drugs for the treatment of Alzheimer's disease

2012
In this book chapter, we first introduce the concept of multitargeted drugs in neurodegenerative diseases. Then, we report and discuss some examples of multitargeted drug candidates in (pre)clinical trials for the treatment of Alzheimer's disease.
CAVALLI, ANDREA, BOLOGNESI, MARIA LAURA
openaire   +1 more source

Multitarget Drugs

2008
Richard Morphy, Zoran Rankovic
openaire   +1 more source

Multitarget antibacterial drugs: An effective strategy to combat bacterial resistance

2023
Haihong Hao
exaly