Results 31 to 40 of about 226,229 (262)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
A demofobia na democracia moderna
Dados: Revista de Ciências Sociais, 2011 Dans cet article, on cherche à montrer l'existence de principes de démophobie dans la théorie de la démocratie moderne. On observe que des propositions théoriques libérales ont tranché sur le fait de subsumer le demos dans le gouvernement de tous, la ...
Thais Florencio de Aguiar
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Teologi Lokal dalam Konteks Global
Gema Teologika, 2016 Today in the globalization process the poor is marginalized. This reflection is based on the Indonesian context of economic dependence and marginalization of the poor and the powerless.
Johanes Baptista Giyana Banawiratma
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Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Needed but Unwanted. Thomas Hobbes’s Warnings on the Dangers of Multitude, Populism and Democracy
Las Torres de Lucca, 2016 The purpose of this article is to analyse Hobbes’s understanding of democracy. The first part of the article analyses the role of democracy in the social contract.
Mikko Jakonen
doaj
Beyond the Public and the Private : Thomas Spence and the Current Debate on Common Property
Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2016 The purpose of this article is to show the concept of common property of Thomas Spence (1750-1814) as a genealogy of the current political debate about the commons. This debate is characterized by two main ways of conceiving of common property : one that
Matilde Cazzola
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Political Theory, 2014 Benedict Spinoza (1634–1677) is feted as the philosopher par excellence of the popular democratic multitude by Antonio Negri and others. But Spinoza himself expresses a marked ambivalence about the multitude in brief asides, and as for his thoughts on what he calls “the rule of (the) multitude,” that is, democracy, these exist only as meager fragments ...
openaire +2 more sources