Results 61 to 70 of about 1,068,731 (282)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Carnets, 2018 When we listen to a reading by Christophe Manon, we are struck by the originality of a “sound fabric” made of ruptures, where the murmur is a constant stream of music that nothing seems to be able to stop. In the poem of the continuous body-voice that is
Frédérique Cosnier-Laffage
doaj +1 more source
Agency Fact Sheet, Department of Corrections: NCF, FY2007 [PDF]
, 2007 This document produced by the Iowa Department of Administrative Services has been developed to provide a multitude of information about executive branch agencies/department on a single sheet of paper.
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Multitude: production of community
Praktyka Teoretyczna, 2010 The paper is an attempt to reconstruct the notion of multitude which appears in the work of Antonio Negri, Michael Hardt and Paolo Virno. Multitude refers to the emergence of a new social subject, substantially different from the known historical ...
Mikołaj Ratajczak
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Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
DOCTRINAIRE ARCHIETYPES OF MACROECONOMIC POLITICS [PDF]
In modern and democratic society conditions, which is characterized by a multitude of economic doctrines, as a reflection of the multitude of parties system that exists, economic policies are directed and appreciated in comparison with the main ...
Laurentiu Dragomir, Victor Stefan
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Revista de Filosofia Antiga, 2019 In lieu of an abstract, here is a brief excerpt of the content: "L’objection la plus ancienne et la plus redoutable à la démocratie fait valoir que le gouvernement par le peuple dessert le gouvernement pour le peuple.
Charles Girard
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