Results 61 to 70 of about 226,229 (262)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Influence of Spinoza's Concept of the Multitude on Debates about Populism and Representation in Democracies

Journal of Spinoza Studies, 2022
Aurelio Sainz Pezonaga, Francisco Javier Espinosa Antón   +1 more
doaj   +1 more source

Dispensing in the buildings of the multitude and the multitude In the Quran between rejection and acceptance

الأستاذ, 2017
The morphological study has witnessed a great interest and importance since it is considered as the perfect scale for words connotations and criteria.
Prof.Dr. Sajida Mazban Hassan
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Fazer-se multidão: multiplicidade, classe e comum

Ciências Sociais Unisinos, 2017
This article is devoted to studies on the concept of multitude. In order to support the analyzes and elaborations on this concept, the article begins with a brief reflection on how the idea of large groups or collective subject has been seen throughout ...
Bruno Tarin
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Populus: the Birth, Death and Resurrection of the Political Subject (from Cicero to Hobbes)

Социология власти
In this article, the author investigates the evolution of the politicophilosophical concept of the “people” (populus), from its appearance in Ancient Roman texts to Early Modern political thought.
Alexander V. Marey
doaj  

A potência oralizante da multidão: por que os estudos culturais ajudam a compreender a experiência dos muitos na literatura contemporânea

Estudos de Literatura Brasileira Contemporânea, 2014
My aim in this article is to make a triple movement: i) s how how the questions made by cultural studies transform the spaces of legitimation of the literature in so far as are symptoms of important changes in the cultural sphere and in the own concept ...
Luciano Barbosa Justino
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Multitude in Cultural Complexities in Asia

SHS Web of Conferences, 2018
The genesis of human settlements is a continuous process of production and layering of patterns, forms and spaces in different scale levels across historical periods.
Widodo Johannes
doaj   +1 more source