Results 121 to 130 of about 9,030 (299)

Ru‐Doping‐Engineered Oxygen Vacancies in MoO3‐x Nanostructured Films With Ultrahigh Capacitance for Flexible Asymmetric Supercapacitors

Advanced Science, EarlyView.
Ru‐doping‐induced defect engineering enables freestanding Ru–MoO3‐x flexible films with enriched oxygen vacancies, modulated band structure, and enhanced charge transport. The optimized electrode delivers ultrahigh capacitance approaching the theoretical limit of MoO3, while assembled asymmetric supercapacitors exhibit high energy density, wide‐voltage
Xiaoqing Bin, Minhao Sheng, Norman C.‐R. Chen, Xiangyang Liu, Yingji Zhao, Yingyi Liao, Wenxiu Que, Yusuke Asakura, Yusuke Yamauchi   +8 more
wiley   +1 more source

A bioengineered anti‐VEGF protein with high affinity and high concentration for intravitreal treatment of wet age‐related macular degeneration

Bioengineering & Translational Medicine
Intravitreal (IVT) injection of anti‐vascular endothelial growth factor (anti‐VEGF) has greatly improved the treatment of many retinal disorders, including wet age‐related macular degeneration (wAMD), which is the third leading cause of blindness ...
Chengnan Huang, Yuelin Wang, Jinliang Huang, Huiqin Liu, Zhidong Chen, Yang Jiang, Youxin Chen, Feng Qian   +7 more
doaj   +1 more source

Interfacial Electric Field Engineering of High‐Entropy Heterostructures Triggering Self‐Limiting Reconstruction for Industrial‐Scale Electrocatalysis

Advanced Science, EarlyView.
An interfacial electric field engineering strategy is proposed to trigger the self‐limiting surface reconstruction of high‐entropy heterostructures. Driven by this built‐in field, the controlled sacrificial leaching of W evolves a robust active layer, enabling exceptional oxygen evolution performance and ultrastability at ampere‐level current densities
Liang Yan, Yueqi Zhang, Bing Zhang, Jingyi Ye, Hao Li   +4 more
wiley   +1 more source

Synthesis of Nanobioconjugates with a Controlled Average Number of Biomolecules between 1 and 100 per Nanoparticle and Observation of Multivalency Dependent Interaction with Proteins and Cells

, 2016
Multivalency of nanoparticle and associated cooperative binding with biological interface is an important aspect in the development of nanoparticle based bioimaging probes.
Amit Ranjan Maity (1418926), SK Basiruddin (1685314), Arindam Saha (1689469), Nikhil R. Jana (1268586)   +3 more
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science
Traditional targeted protein degradation (TPD) strategies are largely ineffective against membrane proteins, which constitute over 60% of drug targets. To address this, we develop a modular “plug‐and‐play” UPTAB (Ultrahigh‐affinity Protein pairs fused to
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Bioorganic Studies in AIDS: Synthetic Antifungals Against Pneumocystis carinii Based on the Multivalency Concept

, 2014
: We report the syntheses of antifungals containing the novel pharmacophores: oxaziridines, sulfonyloxaziridines, nitrones and nitronyl nitroxides. We hypothesized that multiple copies of the pharmacophore per molecule might be a prerequisite to enhance ...
Cunxiang Chen, Langu Peng, Christian R. Gonzalez, Valeria Balogh-nair   +3 more
core  

Multivalency effects of hemagglutinin component of type B botulinum neurotoxin complex on epithelial barrier disruption [PDF]

Hemagglutinin (HA) is one of the components of botulinum neurotoxin (BoNT) complexes and it promotes the absorption of BoNT through the intestinal epithelium by at least two specific mechanisms: cell surface attachment by carbohydrate binding, and ...
藤永, 由佳子, 00456930, Matsumura, Takuhiro, 74179, 阿松, 翔, 油谷, 雅広, 松村, 拓大, 74182, 74181, 74180, Yutani, Masahiro, Fujinaga, Yukako, 90827346, Amatsu, Sho, 20648810, 60252954   +15 more
core   +1 more source

Antibody‐Precomplexed Hemagglutinin Constructs Multivalently Bind Sialylated Glycan Receptors with Variable Valencies

Advanced Materials Interfaces
Antibody precomplexation is a well‐known method to enhance the valency and affinity of hemagglutinin (HA), thus allowing their use in various tests, such as hemagglutination assays.
Daniel Y. E. L. Tambuwun, María Ríos Carrasco, Elif Uslu, Geert‐Jan P. H. Boons, Nadia J. Mokiem, Albert J. R. Heck, Victor C. Yin, Robert P. deVries, Jurriaan Huskens   +8 more
doaj   +1 more source