Results 191 to 200 of about 24,932 (285)

The logarithmic derivative of multivalent functions.

Michigan Mathematical Journal, 1980
openaire   +2 more sources

DNA‐Induced Entropic Gain Triggers an Allosteric Switch for Biomolecular Condensation of Heat Shock Transcription Factor 1

Angewandte Chemie, EarlyView.
Hsf1 undergoes phase separation around target DNA, activating stress‐responsive transcription. DNA binding tunes conformational dynamics of Hsf1DBD, which propagates through large‐scale domain rearrangements involving DBD–IDR interactions to regulate phase separation. This hierarchical framework illustrates how local structural events at the side chain
Soichiro Kawagoe, Hiroyuki Kumeta, Tomohide Saio   +2 more
wiley   +2 more sources

Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design. [PDF]

RSC Chem Biol
Pan Z, Pan Y, Zhang H, Chen Z, Zhang Y, Zhang B, Lu A, Zhang G, Yu S.   +8 more
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Light‐Activated Isolation of High‐Quality Mitochondria for Therapeutic Transplantation

Angewandte Chemie, EarlyView.
The Light‐Activated Mitochondrial Isolation (LAMI) platform enables the selective and non‐destructive isolation of high‐purity, metabolically active mitochondria. By integrating modular, ligand‐programmable magnetic probes with photo‐cleavable release, LAMI overcomes long‐standing limitations of conventional isolation methods and provides a robust ...
Hui Liu, Yuxin Jiao, Ting Zhang, Haiwei Wang, Yufei Xue, Jiayu Ding, Yang Ding, Meiling Wang, Weisen Zhang, Hua Bai, Bo Peng, Nicolas H. Voelcker, Lin Li   +12 more
wiley   +2 more sources

Disaccharide-Presenting Iron(II) Complexes as Synthetic Mimics of Natural Glycan Epitopes for Lectin Recognition. [PDF]

Inorg Chem
Kimbro-Norman M, Cushman EM, Guseman AJ, Stauber JM.   +3 more
europepmc   +1 more source

Data‐ and Theory‐Guided Design of Dual‐Role V‐Doped RuO2 for High‐Performance Acidic Oxygen Evolution

Angewandte Chemie, EarlyView.
A data‐ and theory‐guided paradigm, leveraging large‐scale data mining of 718 catalysts and microkinetic modeling, identifies V‐doped RuO2 as optimal for acidic OER. Vanadium doping drives electron withdrawal from Ru centers, generating Lewis acidic sites that polarize O–H bonds and accelerate deprotonation kinetics. Experimental validation achieves an
Zhongliang Liu, Heng Liu, Kai Zhou, Miaomiao Liu, Tianrui Xue, Jian Zhang, Yiting Song, Jialin Cui, Hao Li, Huihui Li, Chunzhong Li   +10 more
wiley   +2 more sources

Unravelling mechanisms regulating Mincle activation. [PDF]

Commun Biol
Serene LG, Buchanan R, McCarthy AJ, Decout A.   +3 more
europepmc   +1 more source

Advances in BODIPY Derivatives for Antibacterial Phototherapy

Angewandte Chemie, EarlyView.
This review systematically summarizes the design strategies and structure‐activity relationships of BODIPY‐based antibacterial phototherapy, covering molecular engineering of small‐molecule photosensitizers and nanoplatforms, bacterial targeting and carrier design, and discussing the challenges and future perspectives associated with clinical ...
Li Lv, Heejeong Kim, Hongchen Zhai, Hanqi Ren, Silu Wang, Cong Sun, Yafu Wang, Hosoowi Lee, Juyoung Yoon, Hua Zhang   +9 more
wiley   +2 more sources

Advances in engineering and applications of synthetic phase-separated membraneless organelles in biotechnology. [PDF]

Synth Syst Biotechnol
Sun M, Gao AX, Ye B, Zhao Y, Ledesma-Amaro R, Gao J, Wang P.   +6 more
europepmc   +1 more source