Results 151 to 160 of about 1,005,483 (248)

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, EarlyView.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source

First-Line Modified FOLFIRINOX in Metastatic Pancreatic Cancer: Real-World Outcomes and Prognostic Factors From a Vietnamese Cohort. [PDF]

Clin Med Insights Oncol
Nguyen HV, Dinh PT, Tran T, Hoang CT.
europepmc   +1 more source

MULTIVARIATE POINT PROCESSES

, 1972
Cox, D. R., Lewis, P. A. W.
openaire   +2 more sources

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Primary HPV Infection in Postmenopausal Women: A Cohort Study to Enable Risk-Stratified Management. [PDF]

Int J Womens Health
Ye J, Wu G.
europepmc   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

Multi-Platform Multivariate Regression with Group Sparsity for High-Dimensional Data Integration. [PDF]

Entropy (Basel)
Qin S, Zhang G, Gao X, Wu Y.
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Comparable long-term survival outcomes after lobectomy versus total thyroidectomy treatment of minimal extrathyroidal extension differentiated thyroid cancer patients. [PDF]

Gland Surg
Song W, Liu X, Zhou Y, Wang M.
europepmc   +1 more source

Ionic Highways under Multivariate‐Coupled Strategies: Ultrahigh Power Generation from Industrial Waste Liquors Using Robust COF Membranes

Advanced Science, EarlyView.
This study presents a multivariate‐coupled strategy to fabricate TB‐COF membranes with tunable charge density via uniformly distributed Bpy groups, enabling efficient ion transport and energy harvesting. The robust β‐ketoenamine‐linked structure ensures stability, achieving power outputs of 53.08 W m−2 (pH 4), 190.52 W m−2 (low‐grade heat), and 258.81 ...
Hongyan Qi, Weibo Sun, Jundong Zhong, Zhen Xing, Tingting Xu, Shuang Zhao, Haoyang Tan, Ziyi Hu, Hujun Qian, Yuchen Wu, Haibo Zhang, Jianxin Mu, Xuanbo Zhu, Lei Jiang   +13 more
wiley   +1 more source