Results 161 to 170 of about 997,763 (227)

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Prediction of Posterior Communicating Artery Aneurysm Rupture Risk: A Multivariate Analysis of Aneurysm and Surrounding Arterial Morphological Factors. [PDF]

J Clin Med
Nahm M, Ko SW, Yi HJ, Chun HJ, Na MK, Lee YJ, Kim K, Lee SH, Ryu J, Song S, Han K, Choi KS.   +11 more
europepmc   +1 more source

Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

Microbial biotransformation of Syzygium australe modifies metabolomic profile assessed with multivariate analysis and molecular networking: In vitro and computational studies. [PDF]

Sci Rep
Elzayat HH, Seif-Eldein NA, Abdel-Hafez LJM, Ghanem HN, El-Haddad AE, Mohamed SA.   +5 more
europepmc   +1 more source

Multivariate Boosting for Integrative Analysis of High-Dimensional Cancer Genomic Data

Cancer Informatics, 2015
Lie Xiong, Pei-Fen Kuan, Jianan Tian, Sunduz Keles, Sijian Wang   +4 more
doaj  

Exploratory Multivariate Analysis of Mediator Organization in Canine Platelet-Rich Gel Under NSAID Exposure. [PDF]

Gels
Carmona JU, Ospina J, López C.
europepmc   +1 more source

Combined Biospectroscopy with Multivariate Analysis for the Differential Diagnosis of Leptospirosis Disease: A Pilot Study. [PDF]

ACS Omega
Zambrano A, Trilleras J, Arana Rengifo V, Lima KMG, Neves Menezes AC, Morais CLM, Figueira Câmara AB, García Álzate RJ, Piñeres Ariza IE, Romero Vivas CME, Falconar AKI, Cuello-Pèrez M, Carmona Patiño CA.   +12 more
europepmc   +1 more source

Dual diagnosis of acidification dynamics in Amazonian urban lakes: multivariate analysis and calcite saturation index for status and vulnerability assessment. [PDF]

Environ Monit Assess
Noriega C, Romão C, Aquino R, Monteiro S, Moraes B, Brito R, Medeiros C, Rollnic M, Araujo M.   +8 more
europepmc   +1 more source

Harnessing machine learning and multivariate analysis to explore global trends in Cannabis sativa research. [PDF]

J Cannabis Res
De La Hoz-M J, Montes-Escobar K, Salas-Macias CA.   +2 more
europepmc   +1 more source