Results 201 to 210 of about 1,518,144 (228)

Storage Potential of Soil Functional Carbon Fractions in the World's Largest Plantations

open access: yesAdvanced Science, EarlyView.
Climate warming and drying increase the loss of mineral‐associated and particulate organic carbon during the conversion of natural forests to plantations. Based on a survey of the world's largest plantations, the study quantifies the soil carbon deficit in plantations and assesses benchmarks and targets for functional soil organic carbon, highlighting ...
Siyu Ren   +5 more
wiley   +1 more source

The Gut Resistome Atlas in Preterm Infants Enables Prediction of Necrotizing Enterocolitis Onset

open access: yesAdvanced Science, EarlyView.
The gut resistome of preterm infants and its clinical relevance remain poorly understood. This study performs in‐depth integrative analyses of 5,684 gut metagenomes from preterm infants, uncovering distinct features that diverge from term infants. Notably, the gut resistome of preterm infants converges 9 days before necrotizing enterocolitis onset ...
Shuqin Zeng   +22 more
wiley   +1 more source

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

open access: yesAdvanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu   +10 more
wiley   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

open access: yesAdvanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo   +17 more
wiley   +1 more source

Multivariate analysis of the relationship between radiotherapy and malignant gliomas

open access: bronze, 1987
Paul J. Miller   +3 more
openalex   +1 more source

A Herbal‐Piezoelectric Heterojunction Strategy to Potentiate Bacterial Cuproptosis‐Like Death and Remodel the Inflammatory Microenvironment in Infection‐Associated Implant Osteomyelitis

open access: yesAdvanced Science, EarlyView.
A titanium implant coating integrating berberine and copper‐doped strontium titanate leverages ultrasound to compromise bacterial membranes and induce cuproptosis‐like death. This approach resolves S. aureus infections in osteomyelitis models while suppressing inflammation and promoting osseointegration, demonstrating a dual‐functional strategy against
Guannan Zhang   +8 more
wiley   +1 more source

Multi‐Habitat Landscape Promotes Microbial Diversity: Insights from the Traditional Agricultural Heritage and the Global Trend

open access: yesAdvanced Science, EarlyView.
The 2500‐year‐old Mulberry‐dyke and Fish‐pond agricultural heritage system reveals how interconnected habitats foster microbial diversity. Multi‐habitat landscapes enhance microbial diversity through cross‐habitat dispersal and adaptive trait convergence. Globally, regions with diverse habitats support a greater diversity of soil microbiomes.
Jintao He   +8 more
wiley   +1 more source

Lenvatinib Plus Paclitaxel as Second‐Line Therapy for Advanced Gastric Cancer Patients: A Dose Escalation Exploratory Study

open access: yesAdvanced Science, EarlyView.
This study determines the maximum tolerated dose of lenvatinib in combination with paclitaxel as second‐line therapy for advanced gastric cancer patients. A dynamic network biomarker panel associated with patient prognosis and response to treatment is established.
Chenfei Zhou   +8 more
wiley   +1 more source

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