Results 91 to 100 of about 117,319,651 (289)

Multivariate Generalized Linear Mixed Models for Count Data

Austrian Journal of Statistics
Univariate regression models have rich literature for counting data. However, this is not the case for multivariate count data. Therefore, we present the Multivariate Generalized Linear Mixed Models framework that deals with a multivariate set of ...
Guilherme Parreira da Silva, Henrique Aparecido Laureano, Ricardo Rasmussen Petterle, Paulo Justiniano Ribeiro Júnior, Wagner Hugo Bonat   +4 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

A New Approach Based on Cumulants for Estimating Financial Regression Models with Errors in the Variables: the Fama and French Model Revisited [PDF]

This paper proposes to revisit both the CAPM and the three-factor model of Fama and French (1993) in presence of errors in the variables. To reduce the bias induced by measurement and specification errors, we transpose to the cost of equity an estimator ...
Francois-Éric Racicot, Alain Coen
core  

Journal of Multivariate Experimental Personality and Clinical Psychology, v.1, no.3 (complete version)

, 1975
The third issue of the Journal of Multivariate Experimental Personality and Clinical Psychology edited by G.R. Pierson. Editorial policy board: R.B. Cattell, H.J. Eysenck, J.P. Guilford and P.E.

core   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Journal of Multivariate Experimental Personality and Clinical Psychology, v.1, no.4 (complete version)

, 1975
The fourth issue of the Journal of Multivariate Experimental Personality and Clinical Psychology edited by G.R. Pierson. Editorial policy board: R.B. Cattell, H.J. Eysenck, J.P. Guilford and P.E.

core   +1 more source

Observing double Higgs production at the LHC via neutrino feature engineering in $$hh\rightarrow b{\bar{b}}\ell \ell \nu \nu $$ h h → b b ¯ ℓ ℓ ν ν

European Physical Journal C: Particles and Fields
Double Higgs production is challenging even at the High Luminosity LHC. The Standard Model (SM) $$hh\rightarrow b{\bar{b}}WW(ZZ)\rightarrow b{\bar{b}}\ell \ell \nu \nu $$ h h → b b ¯ W W ( Z Z ) → b b ¯ ℓ ℓ ν ν has a moderate cross section compared to ...
Alexandre Alves, Eduardo da Silva Almeida, Diego S. V. Gonçalves   +2 more
doaj   +1 more source

Enhanced Forecasting of Groundwater Level Incorporating an Exogenous Variable: Evaluating Conventional Multivariate Time Series and Artificial Neural Network Models

Geographies
Continuous and uncontrolled extraction of groundwater often creates tremendous pressure on groundwater levels (GWLs). As a part of sustainable planning and effective management of water resources, it is crucial to assess the existing and forecasted GWL ...
Md Abrarul Hoque, Asib Ahmmed Apon, Md Arafat Hassan, Sajal Kumar Adhikary, Md Ariful Islam   +4 more
doaj   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

Advanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku, Jinwon Kwon, Nara Yoon, Hyung Kwon Byeon, Jaemoon Yang   +4 more
wiley   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source